Names & Taxonomy
- Uniprot ID:
- P40238
- Entry Name:
- TPOR_HUMAN
- Status:
- reviewed
- Protein Names:
- Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)
- Gene Names:
- MPL TPOR
- Gene Names Primary:
- MPL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 635
- Sequence:
- MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
- Cross Reference Drug Bank:
- DB06210 DB05332
- Gene Ontology Go:
- cell surface
Golgi apparatus
integral component of plasma membrane
plasma membrane
thrombopoietin receptor activity
transmembrane signaling receptor activity
blood coagulation
cell proliferation
cell surface receptor signaling pathway
platelet activation
thrombopoietin-mediated signaling pathway - Gene Ontology Biological Process:
- blood coagulation
cell proliferation
cell surface receptor signaling pathway
platelet activation
thrombopoietin-mediated signaling pathway - Gene Ontology Molecular Function:
- thrombopoietin receptor activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- cell surface
Golgi apparatus
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Golgi apparatus
Isopeptide bond
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- O60674