Names & Taxonomy

Uniprot ID:
P40238
Entry Name:
TPOR_HUMAN
Status:
reviewed
Protein Names:
Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)
Gene Names:
MPL TPOR
Gene Names Primary:
MPL
Organism:
Homo sapiens (Human)

Structure

Length:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Cross Reference Drug Bank:
DB06210 DB05332
Gene Ontology Go:
cell surface
Golgi apparatus
integral component of plasma membrane
plasma membrane
thrombopoietin receptor activity
transmembrane signaling receptor activity
blood coagulation
cell proliferation
cell surface receptor signaling pathway
platelet activation
thrombopoietin-mediated signaling pathway
Gene Ontology Biological Process:
blood coagulation
cell proliferation
cell surface receptor signaling pathway
platelet activation
thrombopoietin-mediated signaling pathway
Gene Ontology Molecular Function:
thrombopoietin receptor activity
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
cell surface
Golgi apparatus
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Golgi apparatus
Isopeptide bond
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation
Interacts With:
O60674

Publication

PubMed ID:
1608974 8020956 16710414 19880496 10391209 11784712 14764528 15269348 16868251 16470591 16834459 19483125 23441089 25538044