Names & Taxonomy
- Uniprot ID:
- P39656
- Entry Name:
- OST48_HUMAN
- Status:
- reviewed
- Protein Names:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) (EC 2.4.99.18)
- Gene Names:
- DDOST KIAA0115 OST48 OK/SW-cl.45
- Gene Names Orf:
- OK/SW-cl.45
- Gene Names Primary:
- DDOST
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 456
- Sequence:
- MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Function
- Function:
- Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- Dolichyl diphosphooligosaccharide + -L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
oligosaccharyltransferase complex
protein complex
transferase activity, transferring glycosyl groups
cellular protein metabolic process
gene expression
innate immune response
post-translational protein modification
protein glycosylation
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
response to cytokine
SRP-dependent cotranslational protein targeting to membrane
T cell activation
translation - Gene Ontology Biological Process:
- cellular protein metabolic process
gene expression
innate immune response
post-translational protein modification
protein glycosylation
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
response to cytokine
SRP-dependent cotranslational protein targeting to membrane
T cell activation
translation - Gene Ontology Molecular Function:
- transferase activity, transferring glycosyl groups
- Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
oligosaccharyltransferase complex
protein complex - Keywords:
- Alternative splicing
Complete proteome
Congenital disorder of glycosylation
Disease mutation
Endoplasmic reticulum
Glycosyltransferase
Membrane
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- Q86WV6