Names & Taxonomy

Uniprot ID:
P39656
Entry Name:
OST48_HUMAN
Status:
reviewed
Protein Names:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) (EC 2.4.99.18)
Gene Names:
DDOST KIAA0115 OST48 OK/SW-cl.45
Gene Names Orf:
OK/SW-cl.45
Gene Names Primary:
DDOST
Organism:
Homo sapiens (Human)

Structure

Length:
456
Sequence:
MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Function

Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Pathway:
Protein modification; protein glycosylation.
Catalytic Activity:
Dolichyl diphosphooligosaccharide + -L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
oligosaccharyltransferase complex
protein complex
transferase activity, transferring glycosyl groups
cellular protein metabolic process
gene expression
innate immune response
post-translational protein modification
protein glycosylation
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
response to cytokine
SRP-dependent cotranslational protein targeting to membrane
T cell activation
translation
Gene Ontology Biological Process:
cellular protein metabolic process
gene expression
innate immune response
post-translational protein modification
protein glycosylation
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
response to cytokine
SRP-dependent cotranslational protein targeting to membrane
T cell activation
translation
Gene Ontology Molecular Function:
transferase activity, transferring glycosyl groups
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
oligosaccharyltransferase complex
protein complex
Keywords:
Alternative splicing
Complete proteome
Congenital disorder of glycosylation
Disease mutation
Endoplasmic reticulum
Glycosyltransferase
Membrane
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix
Interacts With:
Q86WV6

Publication

PubMed ID:
9367678 7788527 14702039 16710414 15489334 21269460 22016385 24275569 25944712 22305527