Names & Taxonomy

Uniprot ID:
P39060
Entry Name:
COIA1_HUMAN
Status:
reviewed
Protein Names:
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin]
Gene Names:
COL18A1
Gene Names Primary:
COL18A1
Organism:
Homo sapiens (Human)

Structure

Length:
1754
Sequence:
MAPYPCGCHILLLLFCCLAAARANLLNLNWLWFNNEDTSHAATTIPEPQGPLPVQPTADTTTHVTPRNGSTEPATAPGSPEPPSELLEDGQDTPTSAESPDAPEENIAGVGAEILNVAKGIRSFVQLWNDTVPTESLARAETLVLETPVGPLALAGPSSTPQENGTTLWPSRGIPSSPGAHTTEAGTLPAPTPSPPSLGRPWAPLTGPSVPPPSSGRASLSSLLGGAPPWGSLQDPDSQGLSPAAAAPSQQLQRPDVRLRTPLLHPLVMGSLGKHAAPSAFSSGLPGALSQVAVTTLTRDSGAWVSHVANSVGPGLANNSALLGADPEAPAGRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGSVPPPAPPPCCQFCEALQDACWSRLGGGRLPVACASLPTQEDGYCVLIGPAAERISEEVGLLQLLGDPPPQQVTQTDDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPATEGPGVLFAITDSAQAMVLLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVDCEEFQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDEEGDDSDGASGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSRSEEVEEQTTVASLGAQTLPGSDSVSTWDGSVRTPGGRVKEGGLKGQKGEPGVPGPPGRAGPPGSPCLPGPPGLPCPVSPLGPAGPALQTVPGPQGPPGPPGRDGTPGRDGEPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDLEALRGPRGFPGPPGPPGVPGLPGEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGPPGREGPPGRTGQKGSLGEAGAPGHKGSKGAPGPAGARGESGLAGAPGPAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTARSADGPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVPGFPGLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQPGLPGPPGPPGPVVYVSEQDGSVLSVPGPEGRPGFAGFPGPAGPKGNLGSKGERGSPGPKGEKGEPGSIFSPDGGALGPAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGFGMRGMPGPPGPPGPPGPPGTPVYDSNVFAESSRPGPPGLPGNQGPPGPKGAKGEVGPPGPPGQFPFDFLQLEAEMKGEKGDRGDAGQKGERGEPGGGGFFGSSLPGPPGPPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTISVPGPPGPPGPPGPPGTMGASSGVRLWATRQAMLGQVHEVPEGWLIFVAEQEELYVRVQNGFRKVQLEARTPLPRGTDNEVAALQPPVVQLHDSNPYPRREHPHPTARPWRADDILASPPRLPEPQPYPGAPHHSSYVHLRPARPTSPPAHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLGGRLLGQSAASCHHAYIVLCIENSFMTASK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space, extracellular matrix

Function

Function:
COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.; Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
Gene Ontology Go:
basement membrane
collagen trimer
endoplasmic reticulum lumen
extracellular exosome
extracellular matrix
extracellular region
extracellular space
identical protein binding
metal ion binding
structural molecule activity
angiogenesis
cell adhesion
collagen catabolic process
endothelial cell morphogenesis
extracellular matrix disassembly
extracellular matrix organization
negative regulation of cell proliferation
organ morphogenesis
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of endothelial cell apoptotic process
response to drug
response to hydrostatic pressure
visual perception
Gene Ontology Biological Process:
angiogenesis
cell adhesion
collagen catabolic process
endothelial cell morphogenesis
extracellular matrix disassembly
extracellular matrix organization
negative regulation of cell proliferation
organ morphogenesis
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of endothelial cell apoptotic process
response to drug
response to hydrostatic pressure
visual perception
Gene Ontology Molecular Function:
identical protein binding
metal ion binding
structural molecule activity
Gene Ontology Cellular Component:
basement membrane
collagen trimer
endoplasmic reticulum lumen
extracellular exosome
extracellular matrix
extracellular region
extracellular space
Keywords:
3D-structure
Alternative promoter usage
Alternative splicing
Cell adhesion
Collagen
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Hydroxylation
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Zinc
Interacts With:
P05067; P19338; Q15113; P21980

Publication

PubMed ID:
9503365 14614989 10830953 15489334 8188291 11517600 23667181 24275569 9724722 10942434 11606364 14695535 18987736