Names & Taxonomy
- Uniprot ID:
- P38606
- Entry Name:
- VATA_HUMAN
- Status:
- reviewed
- Protein Names:
- V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 3.6.3.14) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
- Gene Names:
- ATP6V1A ATP6A1 ATP6V1A1 VPP2
- Gene Names Primary:
- ATP6V1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 617
- Sequence:
- MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSDYAQLLEDMQNAFRSLED
- Proteomes:
- UP000005640
Function
- Function:
- Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
- Catalytic Activity:
- ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
- Cross Reference Drug Bank:
- DB00630 DB01077 DB01133
- Gene Ontology Go:
- apical plasma membrane
cytosol
extracellular exosome
integral component of plasma membrane
lysosomal membrane
microvillus
mitochondrion
myelin sheath
plasma membrane
proton-transporting two-sector ATPase complex
proton-transporting V-type ATPase, V1 domain
ATP binding
proton-transporting ATPase activity, rotational mechanism
ATP hydrolysis coupled proton transport
ATP metabolic process
cell redox homeostasis
cellular iron ion homeostasis
insulin receptor signaling pathway
ion transmembrane transport
regulation of macroautophagy
transferrin transport
transmembrane transport
transport - Gene Ontology Biological Process:
- ATP hydrolysis coupled proton transport
ATP metabolic process
cell redox homeostasis
cellular iron ion homeostasis
insulin receptor signaling pathway
ion transmembrane transport
regulation of macroautophagy
transferrin transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATP binding
proton-transporting ATPase activity, rotational mechanism - Gene Ontology Cellular Component:
- apical plasma membrane
cytosol
extracellular exosome
integral component of plasma membrane
lysosomal membrane
microvillus
mitochondrion
myelin sheath
plasma membrane
proton-transporting two-sector ATPase complex
proton-transporting V-type ATPase, V1 domain - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Hydrogen ion transport
Hydrolase
Ion transport
Nucleotide-binding
Reference proteome
Transport