Names & Taxonomy

Uniprot ID:
P37023
Entry Name:
ACVL1_HUMAN
Status:
reviewed
Protein Names:
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene Names:
ACVRL1 ACVRLK1 ALK1
Gene Names Primary:
ACVRL1
Organism:
Homo sapiens (Human)

Structure

Length:
503
Sequence:
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Catalytic Activity:
ATP + = ADP + phosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 330 330 Proton acceptor.
Cross Reference Drug Bank:
DB00171
Gene Ontology Go:
cell surface
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
activin binding
activin receptor activity, type I
ATP binding
BMP receptor activity
metal ion binding
protein kinase binding
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
SMAD binding
transforming growth factor beta binding
transforming growth factor beta receptor activity, type I
transforming growth factor beta-activated receptor activity
transmembrane receptor protein serine/threonine kinase activity
activin receptor signaling pathway
angiogenesis
artery development
blood circulation
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
blood vessel maturation
blood vessel remodeling
BMP signaling pathway
cellular response to BMP stimulus
cellular response to transforming growth factor beta stimulus
endothelial tube morphogenesis
in utero embryonic development
lymphangiogenesis
lymphatic endothelial cell differentiation
negative regulation of blood vessel endothelial cell migration
negative regulation of cell adhesion
negative regulation of cell growth
negative regulation of cell migration
negative regulation of cell proliferation
negative regulation of DNA biosynthetic process
negative regulation of endothelial cell differentiation
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
negative regulation of focal adhesion assembly
positive regulation of angiogenesis
positive regulation of BMP signaling pathway
positive regulation of chondrocyte differentiation
positive regulation of endothelial cell differentiation
positive regulation of endothelial cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
protein heterooligomerization
protein phosphorylation
regulation of blood pressure
regulation of blood vessel endothelial cell migration
regulation of DNA replication
regulation of endothelial cell proliferation
regulation of transcription, DNA-templated
retina vasculature development in camera-type eye
signal transduction
transforming growth factor beta receptor signaling pathway
venous blood vessel development
wound healing, spreading of epidermal cells
Gene Ontology Biological Process:
activin receptor signaling pathway
angiogenesis
artery development
blood circulation
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
blood vessel maturation
blood vessel remodeling
BMP signaling pathway
cellular response to BMP stimulus
cellular response to transforming growth factor beta stimulus
endothelial tube morphogenesis
in utero embryonic development
lymphangiogenesis
lymphatic endothelial cell differentiation
negative regulation of blood vessel endothelial cell migration
negative regulation of cell adhesion
negative regulation of cell growth
negative regulation of cell migration
negative regulation of cell proliferation
negative regulation of DNA biosynthetic process
negative regulation of endothelial cell differentiation
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
negative regulation of focal adhesion assembly
positive regulation of angiogenesis
positive regulation of BMP signaling pathway
positive regulation of chondrocyte differentiation
positive regulation of endothelial cell differentiation
positive regulation of endothelial cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein heterooligomerization
protein phosphorylation
regulation of blood pressure
regulation of blood vessel endothelial cell migration
regulation of DNA replication
regulation of endothelial cell proliferation
regulation of transcription, DNA-templated
retina vasculature development in camera-type eye
signal transduction
transforming growth factor beta receptor signaling pathway
venous blood vessel development
wound healing, spreading of epidermal cells
Gene Ontology Molecular Function:
activin binding
activin receptor activity, type I
ATP binding
BMP receptor activity
metal ion binding
protein kinase binding
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
SMAD binding
transforming growth factor beta-activated receptor activity
transforming growth factor beta binding
transforming growth factor beta receptor activity, type I
transmembrane receptor protein serine/threonine kinase activity
Gene Ontology Cellular Component:
cell surface
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
Keywords:
3D-structure
ATP-binding
Angiogenesis
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Kinase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8397373 8242742 9245985 16541075 15489334 22799562 22718755 8640225 10694922 10767348 11170071 11484689 14684682 15024723 15712270 16752392 16525724 20414677 26176610