Names & Taxonomy
- Uniprot ID:
- P36952
- Entry Name:
- SPB5_HUMAN
- Status:
- reviewed
- Protein Names:
- Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)
- Gene Names:
- SERPINB5 PI5
- Gene Names Primary:
- SERPINB5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 375
- Sequence:
- MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
extracellular space
serine-type endopeptidase inhibitor activity
extracellular matrix organization
morphogenesis of an epithelium
movement of cell or subcellular component
negative regulation of endopeptidase activity
prostate gland morphogenesis
regulation of epithelial cell proliferation - Gene Ontology Biological Process:
- extracellular matrix organization
morphogenesis of an epithelium
movement of cell or subcellular component
negative regulation of endopeptidase activity
prostate gland morphogenesis
regulation of epithelial cell proliferation - Gene Ontology Molecular Function:
- serine-type endopeptidase inhibitor activity
- Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Glycoprotein
Polymorphism
Reference proteome
Secreted - Interacts With:
- Q9Y6M0