Names & Taxonomy
- Uniprot ID:
- P36871
- Entry Name:
- PGM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)
- Gene Names:
- PGM1
- Gene Names Primary:
- PGM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 562
- Sequence:
- MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNPGGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cytoplasm.
Function
- Function:
- This enzyme participates in both the breakdown and synthesis of glucose.
- Catalytic Activity:
- Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion per subunit.;
- Active Site:
- ACT_SITE 117 117 Phosphoserine intermediate.
- Gene Ontology Go:
- actin cytoskeleton
cytoplasm
cytosol
extracellular exosome
magnesium ion binding
phosphoglucomutase activity
carbohydrate metabolic process
galactose catabolic process
gluconeogenesis
glucose metabolic process
glycogen biosynthetic process
glycogen catabolic process
glycolytic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
galactose catabolic process
gluconeogenesis
glucose metabolic process
glycogen biosynthetic process
glycogen catabolic process
glycolytic process
small molecule metabolic process - Gene Ontology Molecular Function:
- magnesium ion binding
phosphoglucomutase activity - Gene Ontology Cellular Component:
- actin cytoskeleton
cytoplasm
cytosol
extracellular exosome - Keywords:
- Acetylation
Alternative splicing
Carbohydrate metabolism
Complete proteome
Congenital disorder of glycosylation
Cytoplasm
Disease mutation
Glucose metabolism
Glycogen storage disease
Isomerase
Magnesium
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q9BSI4