Names & Taxonomy
- Uniprot ID:
- P36542
- Entry Name:
- ATPG_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)
- Gene Names:
- ATP5C1 ATP5C ATP5CL1
- Gene Names Primary:
- ATP5C1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 298
- Sequence:
- MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion. Mitochondrion inner membrane
Function
- Function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
- Gene Ontology Go:
- extracellular exosome
membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrial proton-transporting ATP synthase complex
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
mitochondrion
myelin sheath
poly(A) RNA binding
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATPase activity, rotational mechanism
transmembrane transporter activity
ATP biosynthetic process
cellular metabolic process
mitochondrial ATP synthesis coupled proton transport
oxidative phosphorylation
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Biological Process:
- ATP biosynthetic process
cellular metabolic process
mitochondrial ATP synthesis coupled proton transport
oxidative phosphorylation
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Molecular Function:
- poly(A) RNA binding
proton-transporting ATPase activity, rotational mechanism
proton-transporting ATP synthase activity, rotational mechanism
transmembrane transporter activity - Gene Ontology Cellular Component:
- extracellular exosome
membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrial proton-transporting ATP synthase complex
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
mitochondrion
myelin sheath - Keywords:
- ATP synthesis
Acetylation
Alternative splicing
CF(1)
Complete proteome
Direct protein sequencing
Hydrogen ion transport
Ion transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein
Reference proteome
Transit peptide
Transport