Names & Taxonomy
- Uniprot ID:
- P36507
- Entry Name:
- MP2K2_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
- Gene Names:
- MAP2K2 MEK2 MKK2 PRKMK2
- Gene Names Primary:
- MAP2K2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 400
- Sequence:
- MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 194 194 Proton acceptor.
- Cross Reference Drug Bank:
- DB06616 DB08911
- Gene Ontology Go:
- cell cortex
cell-cell junction
cytoplasm
cytoplasmic side of plasma membrane
cytosol
early endosome
endoplasmic reticulum
extracellular region
focal adhesion
Golgi apparatus
late endosome
microtubule
mitochondrion
nucleus
perinuclear region of cytoplasm
peroxisomal membrane
ATP binding
MAP kinase kinase activity
metal ion binding
PDZ domain binding
protein serine/threonine kinase activator activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
scaffold protein binding
activation of MAPK activity
activation of MAPKK activity
axon guidance
epidermal growth factor receptor signaling pathway
epithelial cell proliferation involved in lung morphogenesis
ERK1 and ERK2 cascade
face development
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
heart development
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of gene expression
neurotrophin TRK receptor signaling pathway
peptidyl-serine autophosphorylation
positive regulation of axonogenesis
positive regulation of cell motility
positive regulation of protein serine/threonine kinase activity
Ras protein signal transduction
regulation of apoptotic process
regulation of axon regeneration
regulation of early endosome to late endosome transport
regulation of Golgi inheritance
regulation of mitotic cell cycle
regulation of stress-activated MAPK cascade
small GTPase mediated signal transduction
stress-activated protein kinase signaling cascade
thymus development
thyroid gland development
trachea formation
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPK activity
activation of MAPKK activity
axon guidance
epidermal growth factor receptor signaling pathway
epithelial cell proliferation involved in lung morphogenesis
ERK1 and ERK2 cascade
face development
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
heart development
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of gene expression
neurotrophin TRK receptor signaling pathway
peptidyl-serine autophosphorylation
positive regulation of axonogenesis
positive regulation of cell motility
positive regulation of protein serine/threonine kinase activity
Ras protein signal transduction
regulation of apoptotic process
regulation of axon regeneration
regulation of early endosome to late endosome transport
regulation of Golgi inheritance
regulation of mitotic cell cycle
regulation of stress-activated MAPK cascade
small GTPase mediated signal transduction
stress-activated protein kinase signaling cascade
thymus development
thyroid gland development
trachea formation
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
MAP kinase kinase activity
metal ion binding
PDZ domain binding
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activator activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
scaffold protein binding - Gene Ontology Cellular Component:
- cell-cell junction
cell cortex
cytoplasm
cytoplasmic side of plasma membrane
cytosol
early endosome
endoplasmic reticulum
extracellular region
focal adhesion
Golgi apparatus
late endosome
microtubule
mitochondrion
nucleus
perinuclear region of cytoplasm
peroxisomal membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Cardiomyopathy
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Ectodermal dysplasia
Kinase
Magnesium
Membrane
Mental retardation
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase
Tyrosine-protein kinase - Interacts With:
- P10398; P15056; O95273; Q12959; P04049