Names & Taxonomy
- Uniprot ID:
- P36021
- Entry Name:
- MOT8_HUMAN
- Status:
- reviewed
- Protein Names:
- Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)
- Gene Names:
- SLC16A2 MCT8 XPCT
- Gene Names Primary:
- SLC16A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 539
- Sequence:
- MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNGELLPGSPNPEEPI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.
- Cross Reference Drug Bank:
- DB00149 DB00150 DB00135 DB00451 DB01583 DB00119
- Gene Ontology Go:
- integral component of plasma membrane
monocarboxylic acid transmembrane transporter activity
symporter activity
thyroid hormone transmembrane transporter activity
transporter activity
monocarboxylic acid transport
thyroid hormone transport
transport - Gene Ontology Biological Process:
- monocarboxylic acid transport
thyroid hormone transport
transport - Gene Ontology Molecular Function:
- monocarboxylic acid transmembrane transporter activity
symporter activity
thyroid hormone transmembrane transporter activity
transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
- Keywords:
- Acetylation
Cell membrane
Complete proteome
Disease mutation
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport