Names & Taxonomy
- Uniprot ID:
- P35913
- Entry Name:
- PDE6B_HUMAN
- Status:
- reviewed
- Protein Names:
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)
- Gene Names:
- PDE6B PDEB
- Gene Names Primary:
- PDE6B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 854
- Sequence:
- MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Lipid-anchor.
Function
- Function:
- This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
- Catalytic Activity:
- Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Active Site:
- ACT_SITE 557 557 Proton donor.
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- photoreceptor disc membrane
plasma membrane
3',5'-cyclic-GMP phosphodiesterase activity
metal ion binding
GMP metabolic process
phototransduction, visible light
regulation of cytosolic calcium ion concentration
regulation of rhodopsin mediated signaling pathway
retina development in camera-type eye
rhodopsin mediated signaling pathway
visual perception - Gene Ontology Biological Process:
- GMP metabolic process
phototransduction, visible light
regulation of cytosolic calcium ion concentration
regulation of rhodopsin mediated signaling pathway
retina development in camera-type eye
rhodopsin mediated signaling pathway
visual perception - Gene Ontology Molecular Function:
- 3',5'-cyclic-GMP phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- photoreceptor disc membrane
plasma membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Congenital stationary night blindness
Disease mutation
Hydrolase
Lipoprotein
Membrane
Metal-binding
Polymorphism
Prenylation
Reference proteome
Repeat
Retinitis pigmentosa
Sensory transduction
Vision
cGMP