Names & Taxonomy

Uniprot ID:
P35869
Entry Name:
AHR_HUMAN
Status:
reviewed
Protein Names:
Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76)
Gene Names:
AHR BHLHE76
Gene Names Primary:
AHR
Organism:
Homo sapiens (Human)

Structure

Length:
848
Sequence:
MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQHTHVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGFL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Function

Function:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
Cross Reference Drug Bank:
DB01076 DB00499 DB01404 DB01097 DB00379 DB00393
Gene Ontology Go:
cytoplasm
cytosolic aryl hydrocarbon receptor complex
nuclear aryl hydrocarbon receptor complex
nucleoplasm
nucleus
transcription factor complex
aryl hydrocarbon receptor activity
DNA binding
E-box binding
enhancer binding
Hsp90 protein binding
protein dimerization activity
protein heterodimerization activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
apoptotic process
blood vessel development
cell cycle
cellular response to glucocorticoid stimulus
circadian regulation of gene expression
intracellular receptor signaling pathway
negative regulation of transcription, DNA-templated
ovarian follicle development
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of B cell proliferation
regulation of gene expression
regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
response to estradiol
response to toxic substance
response to xenobiotic stimulus
transcription from RNA polymerase II promoter
xenobiotic metabolic process
Gene Ontology Biological Process:
apoptotic process
blood vessel development
cell cycle
cellular response to glucocorticoid stimulus
circadian regulation of gene expression
intracellular receptor signaling pathway
negative regulation of transcription, DNA-templated
ovarian follicle development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of B cell proliferation
regulation of gene expression
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to estradiol
response to toxic substance
response to xenobiotic stimulus
transcription from RNA polymerase II promoter
xenobiotic metabolic process
Gene Ontology Molecular Function:
aryl hydrocarbon receptor activity
DNA binding
E-box binding
enhancer binding
Hsp90 protein binding
protein dimerization activity
protein heterodimerization activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
Gene Ontology Cellular Component:
cytoplasm
cytosolic aryl hydrocarbon receptor complex
nuclear aryl hydrocarbon receptor complex
nucleoplasm
nucleus
transcription factor complex
Keywords:
Acetylation
Activator
Biological rhythms
Cell cycle
Complete proteome
Cytoplasm
DNA-binding
Nucleus
Polymorphism
Receptor
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation
Interacts With:
P27540; P12977; Q8NI08; Q9Y618

Publication

PubMed ID:
8393992 8246913 7883760 12690205 12853948 15489334 16696038 7515333 7961644 10395741 11259615 12213388 12215427 16582008 12213390 22814378 7550366 10739168 11698344 11689007