Names & Taxonomy

Uniprot ID:
P35790
Entry Name:
CHKA_HUMAN
Status:
reviewed
Protein Names:
Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)
Gene Names:
CHKA CHK CKI
Gene Names Primary:
CHKA
Organism:
Homo sapiens (Human)

Structure

Length:
457
Sequence:
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
Pathway:
Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Catalytic Activity:
ATP + choline = ADP + phosphocholine.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.2 mM for choline
Cross Reference Drug Bank:
DB00122
Gene Ontology Go:
cytosol
ATP binding
choline binding
choline kinase activity
cholinesterase activity
drug binding
ethanolamine kinase activity
signal transducer activity
choline metabolic process
ethanolamine metabolic process
glycerophospholipid biosynthetic process
lipid metabolic process
lipid transport
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
response to 3-methylcholanthrene
response to toxic substance
signal transduction
small molecule metabolic process
Gene Ontology Biological Process:
choline metabolic process
ethanolamine metabolic process
glycerophospholipid biosynthetic process
lipid metabolic process
lipid transport
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
response to 3-methylcholanthrene
response to toxic substance
signal transduction
small molecule metabolic process
Gene Ontology Molecular Function:
ATP binding
choline binding
choline kinase activity
cholinesterase activity
drug binding
ethanolamine kinase activity
signal transducer activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Phospholipid biosynthesis
Phospholipid metabolism
Polymorphism
Reference proteome
Transferase

Publication

PubMed ID:
1618328 16554811 15489334 19915674 17007874 20299452