Names & Taxonomy
- Uniprot ID:
- P35790
- Entry Name:
- CHKA_HUMAN
- Status:
- reviewed
- Protein Names:
- Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)
- Gene Names:
- CHKA CHK CKI
- Gene Names Primary:
- CHKA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 457
- Sequence:
- MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
- Pathway:
- Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
- Catalytic Activity:
- ATP + choline = ADP + phosphocholine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.2 mM for choline
- Cross Reference Drug Bank:
- DB00122
- Gene Ontology Go:
- cytosol
ATP binding
choline binding
choline kinase activity
cholinesterase activity
drug binding
ethanolamine kinase activity
signal transducer activity
choline metabolic process
ethanolamine metabolic process
glycerophospholipid biosynthetic process
lipid metabolic process
lipid transport
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
response to 3-methylcholanthrene
response to toxic substance
signal transduction
small molecule metabolic process - Gene Ontology Biological Process:
- choline metabolic process
ethanolamine metabolic process
glycerophospholipid biosynthetic process
lipid metabolic process
lipid transport
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
response to 3-methylcholanthrene
response to toxic substance
signal transduction
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
choline binding
choline kinase activity
cholinesterase activity
drug binding
ethanolamine kinase activity
signal transducer activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Phospholipid biosynthesis
Phospholipid metabolism
Polymorphism
Reference proteome
Transferase