Names & Taxonomy
- Uniprot ID:
- P35658
- Entry Name:
- NU214_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)
- Gene Names:
- NUP214 CAIN CAN KIAA0023
- Gene Names Primary:
- NUP214
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2090
- Sequence:
- MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nuclear pore complex. Note=Cytoplasmic filaments.
Function
- Function:
- May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
- Gene Ontology Go:
- cytosol
focal adhesion
intracellular membrane-bounded organelle
nuclear pore
nucleoplasm
nucleus
nuclear export signal receptor activity
transporter activity
carbohydrate metabolic process
cellular protein metabolic process
cellular response to heat
cytokine-mediated signaling pathway
gene expression
gene silencing by RNA
glucose transport
hexose transport
mitotic cell cycle
mitotic nuclear envelope disassembly
modulation by virus of host morphology or physiology
modulation by virus of host process
mRNA export from nucleus
post-translational protein modification
protein export from nucleus
protein import into nucleus
protein sumoylation
regulation of cell cycle
regulation of cellular response to heat
regulation of glucose transport
regulation of mRNA stability
small molecule metabolic process
transmembrane transport
tRNA processing
viral life cycle
viral process
viral transcription - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular protein metabolic process
cellular response to heat
cytokine-mediated signaling pathway
gene expression
gene silencing by RNA
glucose transport
hexose transport
mitotic cell cycle
mitotic nuclear envelope disassembly
modulation by virus of host morphology or physiology
modulation by virus of host process
mRNA export from nucleus
post-translational protein modification
protein export from nucleus
protein import into nucleus
protein sumoylation
regulation of cell cycle
regulation of cellular response to heat
regulation of glucose transport
regulation of mRNA stability
small molecule metabolic process
transmembrane transport
tRNA processing
viral life cycle
viral process
viral transcription - Gene Ontology Molecular Function:
- nuclear export signal receptor activity
transporter activity - Gene Ontology Cellular Component:
- cytosol
focal adhesion
intracellular membrane-bounded organelle
nuclear pore
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Chromosomal rearrangement
Coiled coil
Complete proteome
Glycoprotein
Nuclear pore complex
Nucleus
Phosphoprotein
Polymorphism
Protein transport
Proto-oncogene
Reference proteome
Repeat
Translocation
Transport
mRNA transport