Names & Taxonomy

Uniprot ID:
P35626
Entry Name:
ARBK2_HUMAN
Status:
reviewed
Protein Names:
Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3)
Gene Names:
ADRBK2 BARK2 GRK3
Gene Names Primary:
ADRBK2
Organism:
Homo sapiens (Human)

Structure

Length:
688
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
Proteomes:
UP000005640

Function

Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
Catalytic Activity:
ATP + = ADP + phosphate.
Active Site:
ACT_SITE 317 317 Proton acceptor.
Cross Reference Drug Bank:
DB00171
Gene Ontology Go:
ATP binding
beta-adrenergic receptor kinase activity
G-protein coupled receptor kinase activity
protein kinase activity
receptor internalization
signal transduction
Gene Ontology Biological Process:
receptor internalization
signal transduction
Gene Ontology Molecular Function:
ATP binding
beta-adrenergic receptor kinase activity
G-protein coupled receptor kinase activity
protein kinase activity
Keywords:
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Ubl conjugation

Publication

PubMed ID:
8427589 10591208 20596523 17344846