Names & Taxonomy
- Uniprot ID:
- P35626
- Entry Name:
- ARBK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3)
- Gene Names:
- ADRBK2 BARK2 GRK3
- Gene Names Primary:
- ADRBK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 688
- Sequence:
- MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
- Proteomes:
- UP000005640
Function
- Function:
- Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Active Site:
- ACT_SITE 317 317 Proton acceptor.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- ATP binding
beta-adrenergic receptor kinase activity
G-protein coupled receptor kinase activity
protein kinase activity
receptor internalization
signal transduction - Gene Ontology Biological Process:
- receptor internalization
signal transduction - Gene Ontology Molecular Function:
- ATP binding
beta-adrenergic receptor kinase activity
G-protein coupled receptor kinase activity
protein kinase activity - Keywords:
- ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Ubl conjugation