Names & Taxonomy
- Uniprot ID:
- P35606
- Entry Name:
- COPB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)
- Gene Names:
- COPB2
- Gene Names Primary:
- COPB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 906
- Sequence:
- MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGKDFQPSRSTAQQELDGKPASPTPVIVASHTANKEEKSLLELEVDLDNLELEDIDTTDINLDEDILDD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
- Gene Ontology Go:
- COPI vesicle coat
cytosol
Golgi membrane
transport vesicle
structural molecule activity
cellular protein metabolic process
COPI coating of Golgi vesicle
ER to Golgi vesicle-mediated transport
intra-Golgi vesicle-mediated transport
intracellular protein transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
retrograde vesicle-mediated transport, Golgi to ER
toxin transport - Gene Ontology Biological Process:
- cellular protein metabolic process
COPI coating of Golgi vesicle
ER to Golgi vesicle-mediated transport
intracellular protein transport
intra-Golgi vesicle-mediated transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
retrograde vesicle-mediated transport, Golgi to ER
toxin transport - Gene Ontology Molecular Function:
- structural molecule activity
- Gene Ontology Cellular Component:
- COPI vesicle coat
cytosol
Golgi membrane
transport vesicle - Keywords:
- Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
ER-Golgi transport
Golgi apparatus
Membrane
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transport
WD repeat - Interacts With:
- P19838