Names & Taxonomy
- Uniprot ID:
- P35523
- Entry Name:
- CLCN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle)
- Gene Names:
- CLCN1 CLC1
- Gene Names Primary:
- CLCN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 988
- Sequence:
- MEQSRSQQRGGEQSWWGSDPQYQYMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHPTQIYGHHKEQFSDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDGIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAPPSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEELELVESPGLEEELADILQGPSLRSTDEEDEDELIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 191 198 Helical.
Function
- Function:
- Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
- Gene Ontology Go:
- chloride channel complex
integral component of plasma membrane
plasma membrane
sarcolemma
protein homodimerization activity
voltage-gated chloride channel activity
chloride transmembrane transport
ion transmembrane transport
muscle contraction
neuronal action potential propagation
regulation of anion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- chloride transmembrane transport
ion transmembrane transport
muscle contraction
neuronal action potential propagation
regulation of anion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- protein homodimerization activity
voltage-gated chloride channel activity - Gene Ontology Cellular Component:
- chloride channel complex
integral component of plasma membrane
plasma membrane
sarcolemma - Keywords:
- CBS domain
Cell membrane
Chloride
Chloride channel
Complete proteome
Disease mutation
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel - Interacts With:
- Q92624; Q8IZU0