Names & Taxonomy
- Uniprot ID:
- P35414
- Entry Name:
- APJ_HUMAN
- Status:
- reviewed
- Protein Names:
- Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)
- Gene Names:
- APLNR AGTRL1 APJ
- Gene Names Primary:
- APLNR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 380
- Sequence:
- MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
receptor activity
G-protein coupled receptor signaling pathway
gastrulation
heart development
regulation of body fluid levels - Gene Ontology Biological Process:
- gastrulation
G-protein coupled receptor signaling pathway
heart development
regulation of body fluid levels - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Developmental protein
G-protein coupled receptor
Gastrulation
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix