Names & Taxonomy
- Uniprot ID:
- P35408
- Entry Name:
- PE2R4_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
- Gene Names:
- PTGER4 PTGER2
- Gene Names Primary:
- PTGER4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 488
- Sequence:
- MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
- Cross Reference Drug Bank:
- DB00917 DB00929
- Gene Ontology Go:
- integral component of membrane
neuron projection terminus
neuronal cell body
nuclear membrane
plasma membrane
prostaglandin E receptor activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
bone development
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to mechanical stimulus
cellular response to prostaglandin E stimulus
chemokinesis
ductus arteriosus closure
ERK1 and ERK2 cascade
female pregnancy
immune response
JNK cascade
maternal process involved in parturition
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of cytokine secretion
negative regulation of ductus arteriosus closure
negative regulation of endothelin secretion
negative regulation of eosinophil extravasation
negative regulation of hydrogen peroxide metabolic process
negative regulation of inflammatory response
negative regulation of integrin activation
negative regulation of interleukin-1 alpha secretion
negative regulation of nitric-oxide synthase biosynthetic process
negative regulation of peptide secretion
negative regulation of small intestine smooth muscle contraction
negative regulation of tumor necrosis factor secretion
positive regulation of antral ovarian follicle growth
positive regulation of bone resorption
positive regulation of calcitonin secretion
positive regulation of cAMP biosynthetic process
positive regulation of cell adhesion
positive regulation of cell proliferation
positive regulation of chemokinesis
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytokine secretion
positive regulation of gene expression
positive regulation of hyaluronan biosynthetic process
positive regulation of inflammatory response
positive regulation of interleukin-10 secretion
positive regulation of interleukin-8 production
positive regulation of matrix metallopeptidase secretion
positive regulation of mucus secretion
positive regulation of neutrophil extravasation
positive regulation of osteoblast differentiation
positive regulation of renal sodium excretion
positive regulation of smooth muscle cell migration
positive regulation of substance P secretion, neurotransmission
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of urine volume
positive regulation of wound healing
regulation of circadian sleep/wake cycle, wakefulness
regulation of stress fiber assembly
response to amino acid
response to drug
response to lipopolysaccharide
response to mechanical stimulus
response to progesterone
response to salt
response to water-immersion restraint stress
T-helper cell differentiation - Gene Ontology Biological Process:
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
bone development
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to mechanical stimulus
cellular response to prostaglandin E stimulus
chemokinesis
ductus arteriosus closure
ERK1 and ERK2 cascade
female pregnancy
immune response
JNK cascade
maternal process involved in parturition
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of cytokine secretion
negative regulation of ductus arteriosus closure
negative regulation of endothelin secretion
negative regulation of eosinophil extravasation
negative regulation of hydrogen peroxide metabolic process
negative regulation of inflammatory response
negative regulation of integrin activation
negative regulation of interleukin-1 alpha secretion
negative regulation of nitric-oxide synthase biosynthetic process
negative regulation of peptide secretion
negative regulation of small intestine smooth muscle contraction
negative regulation of tumor necrosis factor secretion
positive regulation of antral ovarian follicle growth
positive regulation of bone resorption
positive regulation of calcitonin secretion
positive regulation of cAMP biosynthetic process
positive regulation of cell adhesion
positive regulation of cell proliferation
positive regulation of chemokinesis
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytokine secretion
positive regulation of gene expression
positive regulation of hyaluronan biosynthetic process
positive regulation of inflammatory response
positive regulation of interleukin-10 secretion
positive regulation of interleukin-8 production
positive regulation of matrix metallopeptidase secretion
positive regulation of mucus secretion
positive regulation of neutrophil extravasation
positive regulation of osteoblast differentiation
positive regulation of renal sodium excretion
positive regulation of smooth muscle cell migration
positive regulation of substance P secretion, neurotransmission
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of urine volume
positive regulation of wound healing
regulation of circadian sleep/wake cycle, wakefulness
regulation of stress fiber assembly
response to amino acid
response to drug
response to lipopolysaccharide
response to mechanical stimulus
response to progesterone
response to salt
response to water-immersion restraint stress
T-helper cell differentiation - Gene Ontology Molecular Function:
- prostaglandin E receptor activity
- Gene Ontology Cellular Component:
- integral component of membrane
neuronal cell body
neuron projection terminus
nuclear membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix