Names & Taxonomy

Uniprot ID:
P35348
Entry Name:
ADA1A_HUMAN
Status:
reviewed
Protein Names:
Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c)
Gene Names:
ADRA1A ADRA1C
Gene Names Primary:
ADRA1A
Organism:
Homo sapiens (Human)

Structure

Length:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Function

Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Cross Reference Drug Bank:
DB01614 DB00346 DB00321 DB00543 DB00182 DB00964 DB01238 DB06216 DB00865 DB01295 DB01200 DB00248 DB01136 DB00477 DB00215 DB00575 DB00363 DB00298 DB01151 DB01576 DB00449 DB00590 DB01142 DB04855 DB00450 DB06262 DB01364 DB00751 DB00668 DB01049 DB01253 DB00696 DB01175 DB00800 DB00875 DB04946 DB00458 DB06706 DB00598 DB06707 DB00408 DB00934 DB01365 DB00610 DB01403 DB00723 DB06148 DB00211 DB00370 DB06711 DB01149 DB00622 DB00699 DB00368 DB00540 DB00334 DB00935 DB01267 DB01186 DB01579 DB00925 DB00692 DB00388 DB00397 DB00457 DB00420 DB01069 DB00777 DB00852 DB01224 DB00734 DB06144 DB06207 DB00706 DB01162 DB06764 DB01622 DB00679 DB00797 DB00656 DB00831 DB00726 DB06694 DB00246 DB01624
Gene Ontology Go:
cytosol
integral component of plasma membrane
nuclear membrane
nucleus
plasma membrane
T-tubule
Z disc
alpha1-adrenergic receptor activity
protein heterodimerization activity
activation of phospholipase C activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adult heart development
aging
apoptotic process
calcium ion transport into cytosol
cell growth
cell-cell signaling
G-protein coupled receptor signaling pathway
intracellular signal transduction
micturition
negative regulation of cell proliferation
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
negative regulation of Rho protein signal transduction
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
organ growth
phospholipase C-activating G-protein coupled receptor signaling pathway
pilomotor reflex
positive regulation of action potential
positive regulation of cardiac muscle contraction
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of MAPK cascade
positive regulation of protein kinase C signaling
positive regulation of smooth muscle contraction
positive regulation of synaptic transmission, GABAergic
positive regulation of systemic arterial blood pressure
positive regulation of the force of heart contraction by epinephrine-norepinephrine
positive regulation of vasoconstriction
response to drug
response to hormone
signal transduction
smooth muscle contraction
Gene Ontology Biological Process:
activation of phospholipase C activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adult heart development
aging
apoptotic process
calcium ion transport into cytosol
cell-cell signaling
cell growth
G-protein coupled receptor signaling pathway
intracellular signal transduction
micturition
negative regulation of cell proliferation
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
negative regulation of Rho protein signal transduction
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
organ growth
phospholipase C-activating G-protein coupled receptor signaling pathway
pilomotor reflex
positive regulation of action potential
positive regulation of cardiac muscle contraction
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of MAPK cascade
positive regulation of protein kinase C signaling
positive regulation of smooth muscle contraction
positive regulation of synaptic transmission, GABAergic
positive regulation of systemic arterial blood pressure
positive regulation of the force of heart contraction by epinephrine-norepinephrine
positive regulation of vasoconstriction
response to drug
response to hormone
signal transduction
smooth muscle contraction
Gene Ontology Molecular Function:
alpha1-adrenergic receptor activity
protein heterodimerization activity
Gene Ontology Cellular Component:
cytosol
integral component of plasma membrane
nuclear membrane
nucleus
plasma membrane
T-tubule
Z disc
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8396931 8024574 8183249 8564208 7737411 7815325 9490024 10493934 14702039 15489334 8196478 18802028 22120526 8832064 15179408 16959974