Names & Taxonomy

Uniprot ID:
P35270
Entry Name:
SPRE_HUMAN
Status:
reviewed
Protein Names:
Sepiapterin reductase (SPR) (EC 1.1.1.153)
Gene Names:
SPR
Gene Names Primary:
SPR
Organism:
Homo sapiens (Human)

Structure

Length:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
Catalytic Activity:
L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH.; L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=14.3 uM for sepiapterin
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
aldo-keto reductase (NADP) activity
NADP binding
sepiapterin reductase activity
nitric oxide biosynthetic process
nitric oxide metabolic process
oxidation-reduction process
regulation of nitric-oxide synthase activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process
Gene Ontology Biological Process:
nitric oxide biosynthetic process
nitric oxide metabolic process
oxidation-reduction process
regulation of nitric-oxide synthase activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process
Gene Ontology Molecular Function:
aldo-keto reductase (NADP) activity
NADP binding
sepiapterin reductase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Dystonia
NADP
Oxidoreductase
Phosphoprotein
Reference proteome

Publication

PubMed ID:
1883349 8440319 14702039 15815621 15489334 9792819 11825621 21269460 24275569 11443547 16650784 17159114