Names & Taxonomy
- Uniprot ID:
- P35270
- Entry Name:
- SPRE_HUMAN
- Status:
- reviewed
- Protein Names:
- Sepiapterin reductase (SPR) (EC 1.1.1.153)
- Gene Names:
- SPR
- Gene Names Primary:
- SPR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
- Catalytic Activity:
- L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH.; L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=14.3 uM for sepiapterin
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
aldo-keto reductase (NADP) activity
NADP binding
sepiapterin reductase activity
nitric oxide biosynthetic process
nitric oxide metabolic process
oxidation-reduction process
regulation of nitric-oxide synthase activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process - Gene Ontology Biological Process:
- nitric oxide biosynthetic process
nitric oxide metabolic process
oxidation-reduction process
regulation of nitric-oxide synthase activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process - Gene Ontology Molecular Function:
- aldo-keto reductase (NADP) activity
NADP binding
sepiapterin reductase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Dystonia
NADP
Oxidoreductase
Phosphoprotein
Reference proteome