Names & Taxonomy
- Uniprot ID:
- P35222
- Entry Name:
- CTNB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Catenin beta-1 (Beta-catenin)
- Gene Names:
- CTNNB1 CTNNB OK/SW-cl.35 PRO2286
- Gene Names Orf:
- OK/SW-cl.35 PRO2286
- Gene Names Primary:
- CTNNB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 781
- Sequence:
- MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus
Function
- Function:
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
- Cross Reference Drug Bank:
- DB03904
- Gene Ontology Go:
- adherens junction
apical part of cell
basolateral plasma membrane
beta-catenin destruction complex
beta-catenin-TCF complex
beta-catenin-TCF7L2 complex
bicellular tight junction
catenin complex
cell cortex
cell junction
cell periphery
cell-cell adherens junction
cell-cell junction
centrosome
cytoplasm
cytosol
dendritic shaft
extracellular exosome
fascia adherens
flotillin complex
focal adhesion
lamellipodium
lateral plasma membrane
membrane
microvillus membrane
nuclear euchromatin
nucleoplasm
nucleus
perinuclear region of cytoplasm
plasma membrane
protein complex
protein-DNA complex
Scrib-APC-beta-catenin complex
spindle pole
synapse
transcription factor complex
Wnt signalosome
Z disc
alpha-catenin binding
androgen receptor binding
cadherin binding
double-stranded DNA binding
enzyme binding
estrogen receptor binding
euchromatin binding
I-SMAD binding
ion channel binding
kinase binding
nuclear hormone receptor binding
protein C-terminus binding
protein phosphatase binding
R-SMAD binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription factor binding
signal transducer activity
SMAD binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
adherens junction assembly
androgen receptor signaling pathway
anterior/posterior axis specification
apoptotic process
bone resorption
branching involved in ureteric bud morphogenesis
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
cell adhesion
cell fate specification
cell maturation
cell-matrix adhesion
cellular component disassembly involved in execution phase of apoptosis
cellular response to fibroblast growth factor stimulus
cellular response to growth factor stimulus
cellular response to indole-3-methanol
cellular response to insulin-like growth factor stimulus
cellular response to lithium ion
cellular response to mechanical stimulus
central nervous system vasculogenesis
chromatin-mediated maintenance of transcription
cranial ganglion development
dopaminergic neuron differentiation
dorsal root ganglion development
dorsal/ventral axis specification
ectoderm development
embryonic axis specification
embryonic brain development
embryonic cranial skeleton morphogenesis
embryonic digit morphogenesis
embryonic foregut morphogenesis
embryonic forelimb morphogenesis
embryonic heart tube development
embryonic hindlimb morphogenesis
embryonic skeletal limb joint morphogenesis
endodermal cell fate commitment
endothelial tube morphogenesis
epithelial cell differentiation involved in prostate gland development
epithelial to mesenchymal transition
epithelial tube branching involved in lung morphogenesis
fungiform papilla formation
gastrulation with mouth forming second
genitalia morphogenesis
glial cell fate determination
hair cell differentiation
hair follicle morphogenesis
hair follicle placode formation
hindbrain development
in utero embryonic development
innate immune response
layer formation in cerebral cortex
lens morphogenesis in camera-type eye
liver development
lung cell differentiation
lung induction
lung-associated mesenchyme development
male genitalia development
mesenchymal cell proliferation involved in lung development
metanephros morphogenesis
midbrain development
midgut development
muscle cell differentiation
myoblast differentiation
negative regulation of apoptotic signaling pathway
negative regulation of cell proliferation
negative regulation of chondrocyte differentiation
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
negative regulation of mitotic cell cycle, embryonic
negative regulation of neuron death
negative regulation of oligodendrocyte differentiation
negative regulation of osteoclast differentiation
negative regulation of protein sumoylation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
nephron tubule formation
neural plate development
neuron migration
odontogenesis of dentin-containing tooth
oocyte development
osteoclast differentiation
oviduct development
pancreas development
patterning of blood vessels
positive regulation of apoptotic process
positive regulation of canonical Wnt signaling pathway
positive regulation of chromatin-mediated maintenance of transcription
positive regulation of determination of dorsal identity
positive regulation of DNA-templated transcription, initiation
positive regulation of endothelial cell differentiation
positive regulation of epithelial cell proliferation involved in prostate gland development
positive regulation of epithelial to mesenchymal transition
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of heparan sulfate proteoglycan biosynthetic process
positive regulation of histone H3-K4 methylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of mesenchymal cell proliferation
positive regulation of muscle cell differentiation
positive regulation of neuroblast proliferation
positive regulation of neuron apoptotic process
positive regulation of osteoblast differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of skeletal muscle tissue development
positive regulation of telomerase activity
positive regulation of telomere maintenance via telomerase
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of type I interferon production
programmed cell death
protein heterooligomerization
protein localization to cell surface
proximal/distal pattern formation
regulation of angiogenesis
regulation of calcium ion import
regulation of centriole-centriole cohesion
regulation of centromeric sister chromatid cohesion
regulation of core promoter binding
regulation of euchromatin binding
regulation of fibroblast proliferation
regulation of myelination
regulation of nephron tubule epithelial cell differentiation
regulation of neurogenesis
regulation of protein localization to cell surface
regulation of secondary heart field cardioblast proliferation
regulation of smooth muscle cell proliferation
regulation of T cell proliferation
renal inner medulla development
renal outer medulla development
renal vesicle formation
response to activity
response to cadmium ion
response to cytokine
response to drug
response to estradiol
Schwann cell proliferation
single organismal cell-cell adhesion
small GTPase mediated signal transduction
smooth muscle cell differentiation
stem cell population maintenance
sympathetic ganglion development
synapse organization
synaptic transmission
synaptic vesicle transport
T cell differentiation in thymus
thymus development
trachea formation
transcription, DNA-templated
Wnt signaling pathway - Gene Ontology Biological Process:
- adherens junction assembly
androgen receptor signaling pathway
anterior/posterior axis specification
apoptotic process
bone resorption
branching involved in ureteric bud morphogenesis
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
cell adhesion
cell fate specification
cell-matrix adhesion
cell maturation
cellular component disassembly involved in execution phase of apoptosis
cellular response to fibroblast growth factor stimulus
cellular response to growth factor stimulus
cellular response to indole-3-methanol
cellular response to insulin-like growth factor stimulus
cellular response to lithium ion
cellular response to mechanical stimulus
central nervous system vasculogenesis
chromatin-mediated maintenance of transcription
cranial ganglion development
dopaminergic neuron differentiation
dorsal/ventral axis specification
dorsal root ganglion development
ectoderm development
embryonic axis specification
embryonic brain development
embryonic cranial skeleton morphogenesis
embryonic digit morphogenesis
embryonic foregut morphogenesis
embryonic forelimb morphogenesis
embryonic heart tube development
embryonic hindlimb morphogenesis
embryonic skeletal limb joint morphogenesis
endodermal cell fate commitment
endothelial tube morphogenesis
epithelial cell differentiation involved in prostate gland development
epithelial to mesenchymal transition
epithelial tube branching involved in lung morphogenesis
fungiform papilla formation
gastrulation with mouth forming second
genitalia morphogenesis
glial cell fate determination
hair cell differentiation
hair follicle morphogenesis
hair follicle placode formation
hindbrain development
innate immune response
in utero embryonic development
layer formation in cerebral cortex
lens morphogenesis in camera-type eye
liver development
lung-associated mesenchyme development
lung cell differentiation
lung induction
male genitalia development
mesenchymal cell proliferation involved in lung development
metanephros morphogenesis
midbrain development
midgut development
muscle cell differentiation
myoblast differentiation
negative regulation of apoptotic signaling pathway
negative regulation of cell proliferation
negative regulation of chondrocyte differentiation
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
negative regulation of mitotic cell cycle, embryonic
negative regulation of neuron death
negative regulation of oligodendrocyte differentiation
negative regulation of osteoclast differentiation
negative regulation of protein sumoylation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
nephron tubule formation
neural plate development
neuron migration
odontogenesis of dentin-containing tooth
oocyte development
osteoclast differentiation
oviduct development
pancreas development
patterning of blood vessels
positive regulation of apoptotic process
positive regulation of canonical Wnt signaling pathway
positive regulation of chromatin-mediated maintenance of transcription
positive regulation of determination of dorsal identity
positive regulation of DNA-templated transcription, initiation
positive regulation of endothelial cell differentiation
positive regulation of epithelial cell proliferation involved in prostate gland development
positive regulation of epithelial to mesenchymal transition
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of heparan sulfate proteoglycan biosynthetic process
positive regulation of histone H3-K4 methylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of mesenchymal cell proliferation
positive regulation of muscle cell differentiation
positive regulation of neuroblast proliferation
positive regulation of neuron apoptotic process
positive regulation of osteoblast differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of skeletal muscle tissue development
positive regulation of telomerase activity
positive regulation of telomere maintenance via telomerase
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of type I interferon production
programmed cell death
protein heterooligomerization
protein localization to cell surface
proximal/distal pattern formation
regulation of angiogenesis
regulation of calcium ion import
regulation of centriole-centriole cohesion
regulation of centromeric sister chromatid cohesion
regulation of core promoter binding
regulation of euchromatin binding
regulation of fibroblast proliferation
regulation of myelination
regulation of nephron tubule epithelial cell differentiation
regulation of neurogenesis
regulation of protein localization to cell surface
regulation of secondary heart field cardioblast proliferation
regulation of smooth muscle cell proliferation
regulation of T cell proliferation
renal inner medulla development
renal outer medulla development
renal vesicle formation
response to activity
response to cadmium ion
response to cytokine
response to drug
response to estradiol
Schwann cell proliferation
single organismal cell-cell adhesion
small GTPase mediated signal transduction
smooth muscle cell differentiation
stem cell population maintenance
sympathetic ganglion development
synapse organization
synaptic transmission
synaptic vesicle transport
T cell differentiation in thymus
thymus development
trachea formation
transcription, DNA-templated
Wnt signaling pathway - Gene Ontology Molecular Function:
- alpha-catenin binding
androgen receptor binding
cadherin binding
double-stranded DNA binding
enzyme binding
estrogen receptor binding
euchromatin binding
ion channel binding
I-SMAD binding
kinase binding
nuclear hormone receptor binding
protein C-terminus binding
protein phosphatase binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription factor binding
R-SMAD binding
signal transducer activity
SMAD binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding - Gene Ontology Cellular Component:
- adherens junction
apical part of cell
basolateral plasma membrane
beta-catenin destruction complex
beta-catenin-TCF7L2 complex
beta-catenin-TCF complex
bicellular tight junction
catenin complex
cell-cell adherens junction
cell-cell junction
cell cortex
cell junction
cell periphery
centrosome
cytoplasm
cytosol
dendritic shaft
extracellular exosome
fascia adherens
flotillin complex
focal adhesion
lamellipodium
lateral plasma membrane
membrane
microvillus membrane
nuclear euchromatin
nucleoplasm
nucleus
perinuclear region of cytoplasm
plasma membrane
protein complex
protein-DNA complex
Scrib-APC-beta-catenin complex
spindle pole
synapse
transcription factor complex
Wnt signalosome
Z disc - Keywords:
- 3D-structure
Acetylation
Activator
Alternative splicing
Cell adhesion
Cell junction
Cell membrane
Chromosomal rearrangement
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Glycoprotein
Membrane
Mental retardation
Neurogenesis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
S-nitrosylation
Transcription
Transcription regulation
Ubl conjugation
Wnt signaling pathway - Interacts With:
- P00519; O43707; P25054; P10275; O15169; O35625; O00512; A1Z199; Q9Y297; P33724; Q6P1J9; P12830; P19022; P33151; Q92793; P26231; Q9NSA3; Q9NYF0; P18146; P50402; Q9UKB1; Q96AC1; P11362; P17948; Q08050; Q9BZE0; P49841; P42858; P08069; P18012; P46940; O75564; P14923; Q14678; Q2LD37; Q9UJU2; Q8WVC0; Q9JHQ5; Q9GZQ8; P19838; P29474; Q8TEW0; P16284; Q99697; P49768; Q03431; Q13308; P08575; P23470; Q12913; P49023; Q04206; Q13761; P63208; Q9H6I2; P15884; P36402; Q9NQB0; Q9UKE5; P11388; O95071; Q9GZV5; Q9EPK5; P46937; P46937-3
Publication
- PubMed ID:
- 7806582 14702039 16641997 15489334 12019147 7982500 9020842 10029085 10187801 10966653 11703283 11751639 11279024 11590244 11389839 11389840 11464291 12501215 12051714 12297051 12027456 11834740 12077367 12370829 12420223 12830000 10679188 12640114 12712206 14595118 16424001 17047063 17081983 16858403 17524503 17289029 17009320 18077326 18086858 18220336 18819930 18378692 18669648 19816403 18957423 19690332 20307497 20164195 19996314 19693690 20026641 20068231 21269460 21262353 21132015 21247902 21406692 22647378 22699938 22155184 23033978 22814378 24342833 24275569 25266658 24824780 25807484 11136974 11713475 11713476 12408824 17052462 9065402 9927029 10398436 10391090 10655994 10192393 10435629 10666372 25326669