Names & Taxonomy
- Uniprot ID:
- P35218
- Entry Name:
- CAH5A_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)
- Gene Names:
- CA5A CA5
- Gene Names Primary:
- CA5A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 305
- Sequence:
- MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Reversible hydration of carbon dioxide. Low activity.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.0 mM for CO(2)
- Enzyme Regulation:
- ENZYME REGULATION: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt).
- Active Site:
- ACT_SITE 164 164
- Cross Reference Drug Bank:
- DB01194 DB00909
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
zinc ion binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- Complete proteome
Direct protein sequencing
Disease mutation
Lyase
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Zinc