Names & Taxonomy

Uniprot ID:
P35218
Entry Name:
CAH5A_HUMAN
Status:
reviewed
Protein Names:
Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)
Gene Names:
CA5A CA5
Gene Names Primary:
CA5A
Organism:
Homo sapiens (Human)

Structure

Length:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion.

Function

Function:
Reversible hydration of carbon dioxide. Low activity.
Catalytic Activity:
H(2)CO(3) = CO(2) + H(2)O.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.0 mM for CO(2)
Enzyme Regulation:
ENZYME REGULATION: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt).
Active Site:
ACT_SITE 164 164
Cross Reference Drug Bank:
DB01194 DB00909
Gene Ontology Go:
mitochondrial matrix
mitochondrion
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
carbonate dehydratase activity
zinc ion binding
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
Complete proteome
Direct protein sequencing
Disease mutation
Lyase
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Zinc

Publication

PubMed ID:
8356065 7490083 15489334 16807956 16686544 17127057 17314045 19186056 19206230 18618712 24275569 24530203