Names & Taxonomy

Uniprot ID:
P34913
Entry Name:
HYES_HUMAN
Status:
reviewed
Protein Names:
Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]
Gene Names:
EPHX2
Gene Names Primary:
EPHX2
Organism:
Homo sapiens (Human)

Structure

Length:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Peroxisome.

Function

Function:
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.
Catalytic Activity:
An epoxide + H(2)O = a glycol.; (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=21 uM for threo-9,10-phosphonooxy-hydroxy-octadecanoic acid
Active Site:
ACT_SITE 335 335 Nucleophile.; ACT_SITE 466 466 Proton donor.; ACT_SITE 524 524 Proton acceptor.
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
peroxisome
10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
epoxide hydrolase activity
lipid phosphatase activity
magnesium ion binding
phosphatase activity
protein homodimerization activity
receptor binding
toxic substance binding
arachidonic acid metabolic process
cellular calcium ion homeostasis
cholesterol homeostasis
dephosphorylation
drug metabolic process
epoxygenase P450 pathway
inflammatory response
phospholipid dephosphorylation
positive regulation of gene expression
positive regulation of vasodilation
reactive oxygen species metabolic process
regulation of blood pressure
regulation of cholesterol metabolic process
response to toxic substance
small molecule metabolic process
stilbene catabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
arachidonic acid metabolic process
cellular calcium ion homeostasis
cholesterol homeostasis
dephosphorylation
drug metabolic process
epoxygenase P450 pathway
inflammatory response
phospholipid dephosphorylation
positive regulation of gene expression
positive regulation of vasodilation
reactive oxygen species metabolic process
regulation of blood pressure
regulation of cholesterol metabolic process
response to toxic substance
small molecule metabolic process
stilbene catabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
epoxide hydrolase activity
lipid phosphatase activity
magnesium ion binding
phosphatase activity
protein homodimerization activity
receptor binding
toxic substance binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
peroxisome
Keywords:
3D-structure
Acetylation
Alternative splicing
Aromatic hydrocarbons catabolism
Complete proteome
Cytoplasm
Detoxification
Direct protein sequencing
Hydrolase
Lipid metabolism
Lipoprotein
Magnesium
Metal-binding
Multifunctional enzyme
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
8342951 8619856 10862610 14702039 16421571 15489334 12869654 12574508 12574510 15196990 19608861 21269460 21164107 24275569 15096040 16322563 19746975 19969453 20934334