Names & Taxonomy
- Uniprot ID:
- P34096
- Entry Name:
- RNAS4_HUMAN
- Status:
- reviewed
- Protein Names:
- Ribonuclease 4 (RNase 4) (EC 3.1.27.-)
- Gene Names:
- RNASE4 RNS4
- Gene Names Primary:
- RNASE4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 147
- Sequence:
- MALQRTHSLLLLLLLTLLGLGLVQPSYGQDGMYQRFLRQHVHPEETGGSDRYCNLMMQRRKMTLYHCKRFNTFIHEDIWNIRSICSTTNIQCKNGKMNCHEGVVKVTDCRDTGSSRAPNCRYRAIASTRRVVIACEGNPQVPVHFDG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- This RNase has marked specificity towards the 3' side of uridine nucleotides.
- Active Site:
- ACT_SITE 40 40 Proton acceptor.; ACT_SITE 144 144 Proton donor.
- Gene Ontology Go:
- extracellular exosome
extracellular region
endonuclease activity
nucleic acid binding
ribonuclease A activity
ribonuclease activity
mRNA cleavage
RNA phosphodiester bond hydrolysis, endonucleolytic - Gene Ontology Biological Process:
- mRNA cleavage
RNA phosphodiester bond hydrolysis, endonucleolytic - Gene Ontology Molecular Function:
- endonuclease activity
nucleic acid binding
ribonuclease A activity
ribonuclease activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Endonuclease
Hydrolase
Nuclease
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal