Names & Taxonomy
- Uniprot ID:
- P33981
- Entry Name:
- TTK_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
- Gene Names:
- TTK MPS1 MPS1L1
- Gene Names Primary:
- TTK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 857
- Sequence:
- MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK
- Proteomes:
- UP000005640
Function
- Function:
- Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by the ATP-competitive kinase inhibitor, SP600125.
- Active Site:
- ACT_SITE 647 647 Proton acceptor.
- Gene Ontology Go:
- membrane
spindle
ATP binding
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
chromosome separation
mitotic spindle assembly checkpoint
mitotic spindle organization
peptidyl-tyrosine phosphorylation
positive regulation of cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
spindle organization - Gene Ontology Biological Process:
- chromosome separation
mitotic spindle assembly checkpoint
mitotic spindle organization
peptidyl-tyrosine phosphorylation
positive regulation of cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
spindle organization - Gene Ontology Molecular Function:
- ATP binding
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity - Gene Ontology Cellular Component:
- membrane
spindle - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Tyrosine-protein kinase