Names & Taxonomy

Uniprot ID:
P33527
Entry Name:
MRP1_HUMAN
Status:
reviewed
Protein Names:
Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter)
Gene Names:
ABCC1 MRP MRP1
Gene Names Primary:
ABCC1
Organism:
Homo sapiens (Human)

Structure

Length:
1531
Sequence:
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Cross Reference Drug Bank:
DB05812 DB00345 DB00701 DB01072 DB01076 DB02659 DB01394 DB00286 DB00091 DB00970 DB00694 DB00586 DB01248 DB00997 DB00445 DB00199 DB00773 DB00693 DB00143 DB01016 DB01050 DB01177 DB00224 DB00328 DB00762 DB00602 DB00709 DB00563 DB00834 DB01204 DB01165 DB01229 DB01174 DB01032 DB00396 DB01045 DB00503 DB01098 DB01232 DB06335 DB01138 DB05294 DB08881 DB00661 DB00570 DB00541 DB00399
Gene Ontology Go:
basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
ATP binding
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
transporter activity
arachidonic acid metabolic process
cobalamin metabolic process
leukotriene metabolic process
response to drug
small molecule metabolic process
transmembrane transport
transport
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
arachidonic acid metabolic process
cobalamin metabolic process
leukotriene metabolic process
response to drug
small molecule metabolic process
transmembrane transport
transport
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
ATP binding
transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
Keywords:
3D-structure
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
1360704 8098549 9344662 15616553 10493829 9295302 9334225 9485377 10064732 11114332 11469806 11278867 11278596 15208328 15260484 17081983 16230346 18691976 19413330 19690332 20068231 21269460 21406692 24275569 16697012 10835642 10811882 11721885 11139250 11266082 18987736