Names & Taxonomy
- Uniprot ID:
- P33527
- Entry Name:
- MRP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter)
- Gene Names:
- ABCC1 MRP MRP1
- Gene Names Primary:
- ABCC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1531
- Sequence:
- MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
- Cross Reference Drug Bank:
- DB05812 DB00345 DB00701 DB01072 DB01076 DB02659 DB01394 DB00286 DB00091 DB00970 DB00694 DB00586 DB01248 DB00997 DB00445 DB00199 DB00773 DB00693 DB00143 DB01016 DB01050 DB01177 DB00224 DB00328 DB00762 DB00602 DB00709 DB00563 DB00834 DB01204 DB01165 DB01229 DB01174 DB01032 DB00396 DB01045 DB00503 DB01098 DB01232 DB06335 DB01138 DB05294 DB08881 DB00661 DB00570 DB00541 DB00399
- Gene Ontology Go:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
ATP binding
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
transporter activity
arachidonic acid metabolic process
cobalamin metabolic process
leukotriene metabolic process
response to drug
small molecule metabolic process
transmembrane transport
transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
cobalamin metabolic process
leukotriene metabolic process
response to drug
small molecule metabolic process
transmembrane transport
transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- ATPase activity
ATPase activity, coupled to transmembrane movement of substances
ATP binding
transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport