Names & Taxonomy
- Uniprot ID:
- P33402
- Entry Name:
- GCYA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)
- Gene Names:
- GUCY1A2 GUC1A2 GUCSA2
- Gene Names Primary:
- GUCY1A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 732
- Sequence:
- MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Has guanylyl cyclase on binding to the beta-1 subunit.; Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
- Catalytic Activity:
- GTP = 3',5'-cyclic GMP + diphosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions.
- Cross Reference Drug Bank:
- DB01020 DB00435
- Gene Ontology Go:
- guanylate cyclase complex, soluble
plasma membrane
GTP binding
guanylate cyclase activity
heme binding
blood coagulation
intracellular signal transduction
positive regulation of cGMP biosynthetic process
signal transduction - Gene Ontology Biological Process:
- blood coagulation
intracellular signal transduction
positive regulation of cGMP biosynthetic process
signal transduction - Gene Ontology Molecular Function:
- GTP binding
guanylate cyclase activity
heme binding - Gene Ontology Cellular Component:
- guanylate cyclase complex, soluble
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
GTP-binding
Lyase
Nucleotide-binding
Polymorphism
Reference proteome
cGMP biosynthesis