Names & Taxonomy

Uniprot ID:
P33402
Entry Name:
GCYA2_HUMAN
Status:
reviewed
Protein Names:
Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)
Gene Names:
GUCY1A2 GUC1A2 GUCSA2
Gene Names Primary:
GUCY1A2
Organism:
Homo sapiens (Human)

Structure

Length:
732
Sequence:
MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Has guanylyl cyclase on binding to the beta-1 subunit.; Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
Catalytic Activity:
GTP = 3',5'-cyclic GMP + diphosphate.
Enzyme Regulation:
ENZYME REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions.
Cross Reference Drug Bank:
DB01020 DB00435
Gene Ontology Go:
guanylate cyclase complex, soluble
plasma membrane
GTP binding
guanylate cyclase activity
heme binding
blood coagulation
intracellular signal transduction
positive regulation of cGMP biosynthetic process
signal transduction
Gene Ontology Biological Process:
blood coagulation
intracellular signal transduction
positive regulation of cGMP biosynthetic process
signal transduction
Gene Ontology Molecular Function:
GTP binding
guanylate cyclase activity
heme binding
Gene Ontology Cellular Component:
guanylate cyclase complex, soluble
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Cytoplasm
GTP-binding
Lyase
Nucleotide-binding
Polymorphism
Reference proteome
cGMP biosynthesis

Publication

PubMed ID:
1683630 7673142 16554811 15489334 16959974