Names & Taxonomy
- Uniprot ID:
- P33260
- Entry Name:
- CP2CI_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c)
- Gene Names:
- CYP2C18
- Gene Names Primary:
- CYP2C18
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 490
- Sequence:
- MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB01424 DB01435 DB00921 DB00349 DB01559 DB00531 DB00250 DB01151 DB00829 DB00586 DB01075 DB01181 DB00458 DB00448 DB00281 DB00333 DB00338 DB00082 DB00850 DB01174 DB00252 DB00818 DB01124 DB00755 DB01361 DB00313 DB00661 DB06684 DB00682
- Gene Ontology Go:
- endoplasmic reticulum membrane
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
monooxygenase activity
oxygen binding
steroid hydroxylase activity
epoxygenase P450 pathway
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- epoxygenase P450 pathway
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
monooxygenase activity
oxygen binding
steroid hydroxylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome