Names & Taxonomy

Uniprot ID:
P33151
Entry Name:
CADH5_HUMAN
Status:
reviewed
Protein Names:
Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Gene Names:
CDH5
Gene Names Primary:
CDH5
Organism:
Homo sapiens (Human)

Structure

Length:
784
Sequence:
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction

Function

Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Cross Reference Drug Bank:
DB00480
Gene Ontology Go:
adherens junction
bicellular tight junction
cell junction
cell surface
cell-cell junction
external side of plasma membrane
integral component of membrane
membrane
plasma membrane
beta-catenin binding
calcium ion binding
ion channel binding
receptor binding
adherens junction organization
blood vessel maturation
cell junction assembly
cell-cell junction assembly
cell-cell junction organization
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell proliferation
positive regulation of establishment of endothelial barrier
regulation of establishment of cell polarity
single organismal cell-cell adhesion
transforming growth factor beta receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
adherens junction organization
blood vessel maturation
cell-cell junction assembly
cell-cell junction organization
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell proliferation
positive regulation of establishment of endothelial barrier
regulation of establishment of cell polarity
single organismal cell-cell adhesion
transforming growth factor beta receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
beta-catenin binding
calcium ion binding
ion channel binding
receptor binding
Gene Ontology Cellular Component:
adherens junction
bicellular tight junction
cell-cell junction
cell junction
cell surface
external side of plasma membrane
integral component of membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
P35222; Q8TEW0; Q9NPB6

Publication

PubMed ID:
7627717 9219219 10861224 15489334 2059658 1522121 16335952 19139490 19996314 20332120 21269602