Names & Taxonomy

Uniprot ID:
P32754
Entry Name:
HPPD_HUMAN
Status:
reviewed
Protein Names:
4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase)
Gene Names:
HPD PPD
Gene Names Primary:
HPD
Organism:
Homo sapiens (Human)

Structure

Length:
393
Sequence:
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
Proteomes:
UP000005640

Function

Function:
Key enzyme in the degradation of tyrosine.
Pathway:
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Catalytic Activity:
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).
Cofactor:
COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Cross Reference Drug Bank:
DB00348
Gene Ontology Go:
cytosol
extracellular exosome
4-hydroxyphenylpyruvate dioxygenase activity
metal ion binding
cellular nitrogen compound metabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tyrosine catabolic process
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tyrosine catabolic process
Gene Ontology Molecular Function:
4-hydroxyphenylpyruvate dioxygenase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
extracellular exosome
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Dioxygenase
Disease mutation
Iron
Mental retardation
Metal-binding
Oxidoreductase
Phenylalanine catabolism
Phosphoprotein
Polymorphism
Reference proteome
Tyrosine catabolism

Publication

PubMed ID:
7851880 8521727 9325050 14702039 16541075 15489334 21269460 22814378 24275569 10942115 11073718