Names & Taxonomy

Uniprot ID:
P32418
Entry Name:
NAC1_HUMAN
Status:
reviewed
Protein Names:
Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)
Gene Names:
SLC8A1 CNC NCX1
Gene Names Primary:
SLC8A1
Organism:
Homo sapiens (Human)

Structure

Length:
973
Sequence:
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Enzyme Regulation:
ENZYME REGULATION: Activated by micromolar levels of Ca(2+).
Cross Reference Drug Bank:
DB00132 DB00159
Gene Ontology Go:
cytosol
dendritic shaft
dendritic spine
integral component of plasma membrane
intercalated disc
microtubule
mitochondrion
plasma membrane
sarcolemma
T-tubule
Z disc
ankyrin binding
calcium ion binding
calcium:sodium antiporter activity
cytoskeletal protein binding
ion channel binding
blood coagulation
calcium ion export
calcium ion homeostasis
calcium ion import
calcium ion transmembrane transport
calcium ion transport into cytosol
cardiac conduction
cardiac muscle cell development
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular response to caffeine
cellular response to cAMP
cellular response to hypoxia
cellular response to reactive oxygen species
cellular sodium ion homeostasis
cytosolic calcium ion transport
ion transport
membrane depolarization during cardiac muscle cell action potential
muscle contraction
negative regulation of cytosolic calcium ion concentration
positive regulation of bone mineralization
positive regulation of fibroblast migration
positive regulation of the force of heart contraction
regulation of cardiac conduction
regulation of cardiac muscle contraction by calcium ion signaling
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cell communication by electrical coupling
regulation of heart rate
regulation of sodium ion transport
regulation of the force of heart contraction
relaxation of cardiac muscle
relaxation of smooth muscle
response to ATP
response to drug
response to glucose
response to hydrogen peroxide
response to immobilization stress
response to muscle stretch
response to nutrient
sodium ion export
sodium ion import
sodium ion transmembrane transport
telencephalon development
transmembrane transport
vascular smooth muscle contraction
Gene Ontology Biological Process:
blood coagulation
calcium ion export
calcium ion homeostasis
calcium ion import
calcium ion transmembrane transport
calcium ion transport into cytosol
cardiac conduction
cardiac muscle cell development
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular response to caffeine
cellular response to cAMP
cellular response to hypoxia
cellular response to reactive oxygen species
cellular sodium ion homeostasis
cytosolic calcium ion transport
ion transport
membrane depolarization during cardiac muscle cell action potential
muscle contraction
negative regulation of cytosolic calcium ion concentration
positive regulation of bone mineralization
positive regulation of fibroblast migration
positive regulation of the force of heart contraction
regulation of cardiac conduction
regulation of cardiac muscle contraction by calcium ion signaling
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cell communication by electrical coupling
regulation of heart rate
regulation of sodium ion transport
regulation of the force of heart contraction
relaxation of cardiac muscle
relaxation of smooth muscle
response to ATP
response to drug
response to glucose
response to hydrogen peroxide
response to immobilization stress
response to muscle stretch
response to nutrient
sodium ion export
sodium ion import
sodium ion transmembrane transport
telencephalon development
transmembrane transport
vascular smooth muscle contraction
Gene Ontology Molecular Function:
ankyrin binding
calcium:sodium antiporter activity
calcium ion binding
cytoskeletal protein binding
ion channel binding
Gene Ontology Cellular Component:
cytosol
dendritic shaft
dendritic spine
integral component of plasma membrane
intercalated disc
microtubule
mitochondrion
plasma membrane
sarcolemma
T-tubule
Z disc
Keywords:
Alternative splicing
Antiport
Calcium
Calcium transport
Calmodulin-binding
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
1374913 11241183 14702039 15815621 10908415 15489334 8048567 1476165 23376057 23506867