Names & Taxonomy
- Uniprot ID:
- P32320
- Entry Name:
- CDD_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase)
- Gene Names:
- CDA CDD
- Gene Names Primary:
- CDA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 146
- Sequence:
- MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ
- Proteomes:
- UP000005640
Function
- Function:
- This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
- Catalytic Activity:
- Cytidine + H(2)O = uridine + NH(3).; 2'deoxycytidine + H(2)O = 2'-deoxyuridine + NH(3).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 67 67 Proton donor.
- Cross Reference Drug Bank:
- DB00928 DB01101 DB00987 DB00441
- Gene Ontology Go:
- cytosol
extracellular region
cytidine deaminase activity
nucleoside binding
protein homodimerization activity
zinc ion binding
cell surface receptor signaling pathway
cytidine deamination
cytosine metabolic process
negative regulation of cell growth
negative regulation of nucleotide metabolic process
nucleobase-containing small molecule metabolic process
protein homotetramerization
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
pyrimidine-containing compound salvage
small molecule metabolic process - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
cytidine deamination
cytosine metabolic process
negative regulation of cell growth
negative regulation of nucleotide metabolic process
nucleobase-containing small molecule metabolic process
protein homotetramerization
pyrimidine-containing compound salvage
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process - Gene Ontology Molecular Function:
- cytidine deaminase activity
nucleoside binding
protein homodimerization activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular region - Keywords:
- 3D-structure
Complete proteome
Hydrolase
Metal-binding
Polymorphism
Reference proteome
Zinc - Interacts With:
- Q9BVV2; Q8TBB1; Q96CS7; P25786; Q147X8; O00560; Q96HA8; O43167