Names & Taxonomy
- Uniprot ID:
- P32245
- Entry Name:
- MC4R_HUMAN
- Status:
- reviewed
- Protein Names:
- Melanocortin receptor 4 (MC4-R)
- Gene Names:
- MC4R
- Gene Names Primary:
- MC4R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 332
- Sequence:
- MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
- Gene Ontology Go:
- integral component of membrane
nucleus
plasma membrane
melanocortin receptor activity
melanocyte-stimulating hormone receptor activity
neuropeptide binding
peptide hormone binding
ubiquitin protein ligase binding
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
diet induced thermogenesis
energy reserve metabolic process
feeding behavior
insulin secretion
negative regulation of feeding behavior
positive regulation of bone resorption
positive regulation of cAMP biosynthetic process
regulation of grooming behavior
response to insulin - Gene Ontology Biological Process:
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
diet induced thermogenesis
energy reserve metabolic process
feeding behavior
insulin secretion
negative regulation of feeding behavior
positive regulation of bone resorption
positive regulation of cAMP biosynthetic process
regulation of grooming behavior
response to insulin - Gene Ontology Molecular Function:
- melanocortin receptor activity
melanocyte-stimulating hormone receptor activity
neuropeptide binding
peptide hormone binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- integral component of membrane
nucleus
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Obesity
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix