Names & Taxonomy
- Uniprot ID:
- P31785
- Entry Name:
- IL2RG_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
- Gene Names:
- IL2RG
- Gene Names Primary:
- IL2RG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 369
- Sequence:
- MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Common subunit for the receptors for a variety of interleukins.
- Cross Reference Drug Bank:
- DB00041 DB00004
- Gene Ontology Go:
- external side of plasma membrane
integral component of plasma membrane
intracellular
membrane
plasma membrane
cytokine receptor activity
interleukin-2 binding
activation of MAPKK activity
axon guidance
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
innate immune response
insulin receptor signaling pathway
interleukin-2-mediated signaling pathway
interleukin-4-mediated signaling pathway
interleukin-7-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
innate immune response
insulin receptor signaling pathway
interleukin-2-mediated signaling pathway
interleukin-4-mediated signaling pathway
interleukin-7-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Molecular Function:
- cytokine receptor activity
interleukin-2 binding - Gene Ontology Cellular Component:
- external side of plasma membrane
integral component of plasma membrane
intracellular
membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Host-virus interaction
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
SCID
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P13232; Q7Z3S9