Names & Taxonomy
- Uniprot ID:
- P31350
- Entry Name:
- RIR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)
- Gene Names:
- RRM2 RR2
- Gene Names Primary:
- RRM2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 389
- Sequence:
- MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
- Pathway:
- Genetic information processing; DNA replication.
- Catalytic Activity:
- 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Active Site:
- ACT_SITE 176 176
- Cross Reference Drug Bank:
- DB00242 DB05260
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
nucleus
ribonucleoside-diphosphate reductase complex
metal ion binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
deoxyribonucleoside diphosphate metabolic process
deoxyribonucleotide biosynthetic process
DNA replication
G1/S transition of mitotic cell cycle
mitotic cell cycle
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
protein heterotetramerization
regulation of transcription involved in G1/S transition of mitotic cell cycle
small molecule metabolic process - Gene Ontology Biological Process:
- deoxyribonucleoside diphosphate metabolic process
deoxyribonucleotide biosynthetic process
DNA replication
G1/S transition of mitotic cell cycle
mitotic cell cycle
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
protein heterotetramerization
regulation of transcription involved in G1/S transition of mitotic cell cycle
small molecule metabolic process - Gene Ontology Molecular Function:
- metal ion binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm
nucleus
ribonucleoside-diphosphate reductase complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA replication
Iron
Metal-binding
Oxidoreductase
Phosphoprotein
Reference proteome - Interacts With:
- P41002; Q9UM11; P23921