Names & Taxonomy

Uniprot ID:
P31350
Entry Name:
RIR2_HUMAN
Status:
reviewed
Protein Names:
Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)
Gene Names:
RRM2 RR2
Gene Names Primary:
RRM2
Organism:
Homo sapiens (Human)

Structure

Length:
389
Sequence:
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Pathway:
Genetic information processing; DNA replication.
Catalytic Activity:
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.
Cofactor:
COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Active Site:
ACT_SITE 176 176
Cross Reference Drug Bank:
DB00242 DB05260
Gene Ontology Go:
cytoplasm
cytosol
nucleoplasm
nucleus
ribonucleoside-diphosphate reductase complex
metal ion binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
deoxyribonucleoside diphosphate metabolic process
deoxyribonucleotide biosynthetic process
DNA replication
G1/S transition of mitotic cell cycle
mitotic cell cycle
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
protein heterotetramerization
regulation of transcription involved in G1/S transition of mitotic cell cycle
small molecule metabolic process
Gene Ontology Biological Process:
deoxyribonucleoside diphosphate metabolic process
deoxyribonucleotide biosynthetic process
DNA replication
G1/S transition of mitotic cell cycle
mitotic cell cycle
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
protein heterotetramerization
regulation of transcription involved in G1/S transition of mitotic cell cycle
small molecule metabolic process
Gene Ontology Molecular Function:
metal ion binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Gene Ontology Cellular Component:
cytoplasm
cytosol
nucleoplasm
nucleus
ribonucleoside-diphosphate reductase complex
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA replication
Iron
Metal-binding
Oxidoreductase
Phosphoprotein
Reference proteome
Interacts With:
P41002; Q9UM11; P23921

Publication

PubMed ID:
1627826 11978970 14702039 15815621 15489334 16964243 17924679 17693683 18691976 18669648 19413330 19690332 20068231 21269460 21406692