Names & Taxonomy
- Uniprot ID:
- P31323
- Entry Name:
- KAP3_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP-dependent protein kinase type II-beta regulatory subunit
- Gene Names:
- PRKAR2B
- Gene Names Primary:
- PRKAR2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 418
- Sequence:
- MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
- Gene Ontology Go:
- cAMP-dependent protein kinase complex
centrosome
ciliary base
cytoplasm
cytosol
dendritic shaft
dendritic spine
extracellular exosome
membrane raft
mitochondrial inner membrane
neuronal cell body
perinuclear region of cytoplasm
plasma membrane
cAMP binding
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
protein kinase A catalytic subunit binding
ubiquitin protein ligase binding
activation of phospholipase C activity
activation of protein kinase A activity
blood coagulation
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fatty acid metabolic process
fibroblast growth factor receptor signaling pathway
G2/M transition of mitotic cell cycle
innate immune response
intracellular signal transduction
learning
mitotic cell cycle
negative regulation of cAMP-dependent protein kinase activity
neurotrophin TRK receptor signaling pathway
organelle organization
regulation of insulin secretion
renal water homeostasis
response to antipsychotic drug
response to clozapine
signal transduction
small molecule metabolic process
transmembrane transport
water transport - Gene Ontology Biological Process:
- activation of phospholipase C activity
activation of protein kinase A activity
blood coagulation
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fatty acid metabolic process
fibroblast growth factor receptor signaling pathway
G2/M transition of mitotic cell cycle
innate immune response
intracellular signal transduction
learning
mitotic cell cycle
negative regulation of cAMP-dependent protein kinase activity
neurotrophin TRK receptor signaling pathway
organelle organization
regulation of insulin secretion
renal water homeostasis
response to antipsychotic drug
response to clozapine
signal transduction
small molecule metabolic process
transmembrane transport
water transport - Gene Ontology Molecular Function:
- cAMP binding
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
protein kinase A catalytic subunit binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cAMP-dependent protein kinase complex
centrosome
ciliary base
cytoplasm
cytosol
dendritic shaft
dendritic spine
extracellular exosome
membrane raft
mitochondrial inner membrane
neuronal cell body
perinuclear region of cytoplasm
plasma membrane - Keywords:
- Acetylation
Cell membrane
Complete proteome
Cytoplasm
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
cAMP
cAMP-binding