Names & Taxonomy
- Uniprot ID:
- P30988
- Entry Name:
- CALCR_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcitonin receptor (CT-R)
- Gene Names:
- CALCR
- Gene Names Primary:
- CALCR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 508
- Sequence:
- MQFSGEKISGQRDLQKSKMRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRKLTTIFPLNWKYRKALSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
- Cross Reference Drug Bank:
- DB01278 DB00017
- Gene Ontology Go:
- cell
integral component of plasma membrane
plasma membrane
calcitonin binding
calcitonin receptor activity
protein transporter activity
receptor activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of adenylate cyclase activity
positive regulation of cAMP biosynthetic process
positive regulation of cytosolic calcium ion concentration
protein localization to plasma membrane
protein transport
receptor internalization
response to glucocorticoid - Gene Ontology Biological Process:
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of adenylate cyclase activity
positive regulation of cAMP biosynthetic process
positive regulation of cytosolic calcium ion concentration
protein localization to plasma membrane
protein transport
receptor internalization
response to glucocorticoid - Gene Ontology Molecular Function:
- calcitonin binding
calcitonin receptor activity
protein transporter activity
receptor activity - Gene Ontology Cellular Component:
- cell
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative promoter usage
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix