Names & Taxonomy
- Uniprot ID:
- P30874
- Entry Name:
- SSR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1)
- Gene Names:
- SSTR2
- Gene Names Primary:
- SSTR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 369
- Sequence:
- MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Function
- Function:
- Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
- Cross Reference Drug Bank:
- DB06791 DB00104 DB06663 DB04894
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
neuron projection
plasma membrane
neuropeptide binding
PDZ domain binding
somatostatin receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cell-cell signaling
cellular response to estradiol stimulus
cellular response to glucocorticoid stimulus
cerebellum development
digestion
forebrain development
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
peristalsis
regulation of muscle contraction
response to nutrient
response to starvation
spermatogenesis - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cell-cell signaling
cellular response to estradiol stimulus
cellular response to glucocorticoid stimulus
cerebellum development
digestion
forebrain development
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
peristalsis
regulation of muscle contraction
response to nutrient
response to starvation
spermatogenesis - Gene Ontology Molecular Function:
- neuropeptide binding
PDZ domain binding
somatostatin receptor activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
neuron projection
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P27986; P32745