Names & Taxonomy
- Uniprot ID:
- P30872
- Entry Name:
- SSR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SRIF-2)
- Gene Names:
- SSTR1
- Gene Names Primary:
- SSTR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 391
- Sequence:
- MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
- Cross Reference Drug Bank:
- DB00104 DB06663
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
neuron projection
plasma membrane
neuropeptide binding
somatostatin receptor activity
cell surface receptor signaling pathway
cell-cell signaling
cellular response to estradiol stimulus
cerebellum development
digestion
forebrain development
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
glutamate receptor signaling pathway
negative regulation of cell proliferation
response to nutrient
response to starvation
spermatogenesis - Gene Ontology Biological Process:
- cell-cell signaling
cell surface receptor signaling pathway
cellular response to estradiol stimulus
cerebellum development
digestion
forebrain development
glutamate receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
response to nutrient
response to starvation
spermatogenesis - Gene Ontology Molecular Function:
- neuropeptide binding
somatostatin receptor activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
neuron projection
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix