Names & Taxonomy

Uniprot ID:
P30825
Entry Name:
CTR1_HUMAN
Status:
reviewed
Protein Names:
High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)
Gene Names:
SLC7A1 ATRC1 ERR REC1L
Gene Names Primary:
SLC7A1
Organism:
Homo sapiens (Human)

Structure

Length:
629
Sequence:
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.
Cross Reference Drug Bank:
DB00125 DB00123 DB00129
Gene Ontology Go:
integral component of plasma membrane
membrane
plasma membrane
antiporter activity
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity
amino acid transport
ion transport
L-lysine transmembrane transport
L-ornithine transmembrane transport
transmembrane transport
transport
Gene Ontology Biological Process:
amino acid transport
ion transport
L-lysine transmembrane transport
L-ornithine transmembrane transport
transmembrane transport
transport
Gene Ontology Molecular Function:
antiporter activity
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
membrane
plasma membrane
Keywords:
Amino-acid transport
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q969F0

Publication

PubMed ID:
1718082 1348489 10485994 15057823 15489334 19349973