Names & Taxonomy
- Uniprot ID:
- P30825
- Entry Name:
- CTR1_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)
- Gene Names:
- SLC7A1 ATRC1 ERR REC1L
- Gene Names Primary:
- SLC7A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 629
- Sequence:
- MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.
- Cross Reference Drug Bank:
- DB00125 DB00123 DB00129
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
antiporter activity
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity
amino acid transport
ion transport
L-lysine transmembrane transport
L-ornithine transmembrane transport
transmembrane transport
transport - Gene Ontology Biological Process:
- amino acid transport
ion transport
L-lysine transmembrane transport
L-ornithine transmembrane transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- antiporter activity
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Amino-acid transport
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q969F0