Names & Taxonomy
- Uniprot ID:
- P30559
- Entry Name:
- OXYR_HUMAN
- Status:
- reviewed
- Protein Names:
- Oxytocin receptor (OT-R)
- Gene Names:
- OXTR
- Gene Names Primary:
- OXTR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 389
- Sequence:
- MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
- Cross Reference Drug Bank:
- DB01282 DB00107
- Gene Ontology Go:
- apical plasma membrane
cell-cell adherens junction
cytosol
integral component of plasma membrane
microvillus
plasma membrane
oxytocin receptor activity
peptide binding
peptide hormone binding
vasopressin receptor activity
cell surface receptor signaling pathway
cellular response to hormone stimulus
digestive tract development
eating behavior
ERK1 and ERK2 cascade
estrous cycle
female pregnancy
heart development
lactation
maternal behavior
maternal process involved in parturition
memory
muscle contraction
negative regulation of gastric acid secretion
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of norepinephrine secretion
positive regulation of penile erection
positive regulation of synapse assembly
positive regulation of synaptic transmission, GABAergic
positive regulation of synaptic transmission, glutamatergic
positive regulation of uterine smooth muscle contraction
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to amphetamine
response to anoxia
response to cocaine
response to cytokine
response to drug
response to estradiol
response to peptide
response to peptide hormone
response to progesterone
sleep
social behavior
sperm ejaculation
suckling behavior
telencephalon development - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
cellular response to hormone stimulus
digestive tract development
eating behavior
ERK1 and ERK2 cascade
estrous cycle
female pregnancy
heart development
lactation
maternal behavior
maternal process involved in parturition
memory
muscle contraction
negative regulation of gastric acid secretion
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of norepinephrine secretion
positive regulation of penile erection
positive regulation of synapse assembly
positive regulation of synaptic transmission, GABAergic
positive regulation of synaptic transmission, glutamatergic
positive regulation of uterine smooth muscle contraction
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
response to amphetamine
response to anoxia
response to cocaine
response to cytokine
response to drug
response to estradiol
response to peptide
response to peptide hormone
response to progesterone
sleep
social behavior
sperm ejaculation
suckling behavior
telencephalon development - Gene Ontology Molecular Function:
- oxytocin receptor activity
peptide binding
peptide hormone binding
vasopressin receptor activity - Gene Ontology Cellular Component:
- apical plasma membrane
cell-cell adherens junction
cytosol
integral component of plasma membrane
microvillus
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix