Names & Taxonomy

Uniprot ID:
P30532
Entry Name:
ACHA5_HUMAN
Status:
reviewed
Protein Names:
Neuronal acetylcholine receptor subunit alpha-5
Gene Names:
CHRNA5 NACHRA5
Gene Names Primary:
CHRNA5
Organism:
Homo sapiens (Human)

Structure

Length:
468
Sequence:
MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cross Reference Drug Bank:
DB00898 DB00674 DB00184
Gene Ontology Go:
acetylcholine-gated channel complex
cell junction
dendrite
neuronal cell body
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
ligand-gated ion channel activity
behavioral response to nicotine
chemical synaptic transmission, postsynaptic
neuromuscular synaptic transmission
signal transduction
synaptic transmission
synaptic transmission, cholinergic
transport
Gene Ontology Biological Process:
behavioral response to nicotine
chemical synaptic transmission, postsynaptic
neuromuscular synaptic transmission
signal transduction
synaptic transmission
synaptic transmission, cholinergic
transport
Gene Ontology Molecular Function:
acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
ligand-gated ion channel activity
Gene Ontology Cellular Component:
acetylcholine-gated channel complex
cell junction
dendrite
neuronal cell body
plasma membrane
postsynaptic membrane
Keywords:
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Interacts With:
P17787

Publication

PubMed ID:
1542648 8906617 9009220 15489334 18385720 18385738 18385676