Names & Taxonomy
- Uniprot ID:
- P30419
- Entry Name:
- NMT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1)
- Gene Names:
- NMT1 NMT
- Gene Names Primary:
- NMT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 496
- Sequence:
- MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
- Catalytic Activity:
- Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
- Gene Ontology Go:
- actin cytoskeleton
cell junction
cytoplasm
cytosol
extrinsic component of membrane
mitochondrion
plasma membrane
glycylpeptide N-tetradecanoyltransferase activity
apoptotic process
in utero embryonic development
intrinsic apoptotic signaling pathway
N-terminal peptidyl-glycine N-myristoylation
phototransduction, visible light
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
programmed cell death
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
viral process - Gene Ontology Biological Process:
- apoptotic process
intrinsic apoptotic signaling pathway
in utero embryonic development
N-terminal peptidyl-glycine N-myristoylation
phototransduction, visible light
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
programmed cell death
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
viral process - Gene Ontology Molecular Function:
- glycylpeptide N-tetradecanoyltransferase activity
- Gene Ontology Cellular Component:
- actin cytoskeleton
cell junction
cytoplasm
cytosol
extrinsic component of membrane
mitochondrion
plasma membrane - Keywords:
- 3D-structure
Acyltransferase
Alternative splicing
Complete proteome
Cytoplasm
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transferase