Names & Taxonomy

Uniprot ID:
P30049
Entry Name:
ATPD_HUMAN
Status:
reviewed
Protein Names:
ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)
Gene Names:
ATP5D
Gene Names Primary:
ATP5D
Organism:
Homo sapiens (Human)

Structure

Length:
168
Sequence:
MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFASPTQVFFNGANVRQVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSIAVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQAELVGTADEATRAEIQIRIEANEALVKALE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion. Mitochondrion inner membrane.

Function

Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Cross Reference Drug Bank:
DB01189 DB00228 DB01159 DB00753 DB01028 DB01236
Gene Ontology Go:
mitochondrial inner membrane
mitochondrial matrix
mitochondrial proton-transporting ATP synthase complex
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
mitochondrion
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATPase activity, rotational mechanism
transmembrane transporter activity
transporter activity
ATP biosynthetic process
ATP synthesis coupled proton transport
cellular metabolic process
mitochondrial ATP synthesis coupled proton transport
oxidative phosphorylation
respiratory electron transport chain
response to copper ion
small molecule metabolic process
Gene Ontology Biological Process:
ATP biosynthetic process
ATP synthesis coupled proton transport
cellular metabolic process
mitochondrial ATP synthesis coupled proton transport
oxidative phosphorylation
respiratory electron transport chain
response to copper ion
small molecule metabolic process
Gene Ontology Molecular Function:
proton-transporting ATPase activity, rotational mechanism
proton-transporting ATP synthase activity, rotational mechanism
transmembrane transporter activity
transporter activity
Gene Ontology Cellular Component:
mitochondrial inner membrane
mitochondrial matrix
mitochondrial proton-transporting ATP synthase complex
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
mitochondrion
Keywords:
ATP synthesis
Acetylation
CF(1)
Complete proteome
Direct protein sequencing
Hydrogen ion transport
Ion transport
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Transit peptide
Transport
Ubl conjugation

Publication

PubMed ID:
1531933 15057824 15489334 1286669 21269460 24275569 25944712