Names & Taxonomy

Uniprot ID:
P29323
Entry Name:
EPHB2_HUMAN
Status:
reviewed
Protein Names:
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3)
Gene Names:
EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5
Gene Names Primary:
EPHB2
Organism:
Homo sapiens (Human)

Structure

Length:
1055
Sequence:
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKKGMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon

Function

Function:
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.
Catalytic Activity:
ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Active Site:
ACT_SITE 746 746 Proton acceptor.
Gene Ontology Go:
axon
cytosol
dendrite
extracellular region
integral component of plasma membrane
neuronal cell body
plasma membrane
ATP binding
axon guidance receptor activity
protein tyrosine kinase activity
transmembrane-ephrin receptor activity
angiogenesis
axon guidance
axonal fasciculation
camera-type eye morphogenesis
central nervous system projection neuron axonogenesis
commissural neuron axon guidance
corpus callosum development
dendritic spine development
dendritic spine morphogenesis
ephrin receptor signaling pathway
inner ear morphogenesis
learning
negative regulation of axonogenesis
nervous system development
optic nerve morphogenesis
palate development
peptidyl-tyrosine phosphorylation
phosphorylation
positive regulation of long-term neuronal synaptic plasticity
positive regulation of synapse assembly
regulation of body fluid levels
retinal ganglion cell axon guidance
urogenital system development
Gene Ontology Biological Process:
angiogenesis
axonal fasciculation
axon guidance
camera-type eye morphogenesis
central nervous system projection neuron axonogenesis
commissural neuron axon guidance
corpus callosum development
dendritic spine development
dendritic spine morphogenesis
ephrin receptor signaling pathway
inner ear morphogenesis
learning
negative regulation of axonogenesis
nervous system development
optic nerve morphogenesis
palate development
peptidyl-tyrosine phosphorylation
phosphorylation
positive regulation of long-term neuronal synaptic plasticity
positive regulation of synapse assembly
regulation of body fluid levels
retinal ganglion cell axon guidance
urogenital system development
Gene Ontology Molecular Function:
ATP binding
axon guidance receptor activity
protein tyrosine kinase activity
transmembrane-ephrin receptor activity
Gene Ontology Cellular Component:
axon
cytosol
dendrite
extracellular region
integral component of plasma membrane
neuronal cell body
plasma membrane
Keywords:
3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cell projection
Complete proteome
Developmental protein
Disease mutation
Disulfide bond
Glycoprotein
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tumor suppressor
Tyrosine-protein kinase
Interacts With:
P49790

Publication

PubMed ID:
8033077 8589679 9696046 16710414 7898931 7601466 7688222 1648701 9267020 10508479 18691976 19369195 9933164 17897949 15300251 16155194 17344846