Names & Taxonomy
- Uniprot ID:
- P29144
- Entry Name:
- TPP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II)
- Gene Names:
- TPP2
- Gene Names Primary:
- TPP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1249
- Sequence:
- MATAATEEPFPFHGLLPKKETGAASFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIVDIIDTTGSGDVNTATEVEPKDGEIVGLSGRVLKIPASWTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPVHRVALAEACRKQEEFDVANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGEVWRACIDSNEDGDLSKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNIIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALILSGLKANNIDYTVHSVRRALENTAVKADNIEVFAQGHGIIQVDKAYDYLVQNTSFANKLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISLQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFIEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLTEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKNWVQTLRPVSAKTKPLGSRDVLPNNRQLYEMVLTYNFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLERLKDLPFIVSHRLSNTLSLDIHENHSFALLGKKKSSNLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSSDIYNELKETYPNYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHTQAQDGAISTDAEGKEEEGESPLDSLAETFWETTKWTDLFDNKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).
- Catalytic Activity:
- Release of an N-terminal tripeptide from a polypeptide.
- Active Site:
- ACT_SITE 44 44 Charge relay system.
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
aminopeptidase activity
endopeptidase activity
peptide binding
serine-type endopeptidase activity
tripeptidyl-peptidase activity
antigen processing and presentation of peptide antigen via MHC class I
protein polyubiquitination
proteolysis - Gene Ontology Biological Process:
- antigen processing and presentation of peptide antigen via MHC class I
protein polyubiquitination
proteolysis - Gene Ontology Molecular Function:
- aminopeptidase activity
endopeptidase activity
peptide binding
serine-type endopeptidase activity
tripeptidyl-peptidase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus - Keywords:
- Acetylation
Aminopeptidase
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Isopeptide bond
Nucleus
Phosphoprotein
Protease
Reference proteome
Serine protease
Ubl conjugation - Interacts With:
- Q08426; P06746; Q96I34