Names & Taxonomy
- Uniprot ID:
- P29074
- Entry Name:
- PTN4_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
- Gene Names:
- PTPN4
- Gene Names Primary:
- PTPN4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 926
- Sequence:
- MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- May act at junctions between the membrane and the cytoskeleton.
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Active Site:
- ACT_SITE 852 852 Phosphocysteine intermediate.
- Cross Reference Drug Bank:
- DB00630
- Gene Ontology Go:
- cytoplasm
cytoplasmic side of plasma membrane
cytoskeleton
non-membrane spanning protein tyrosine phosphatase activity
protein dephosphorylation - Gene Ontology Biological Process:
- protein dephosphorylation
- Gene Ontology Molecular Function:
- non-membrane spanning protein tyrosine phosphatase activity
- Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic side of plasma membrane
cytoskeleton - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome - Interacts With:
- P46108; Q92993; P53778; P16333