Names & Taxonomy

Uniprot ID:
P29074
Entry Name:
PTN4_HUMAN
Status:
reviewed
Protein Names:
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Gene Names:
PTPN4
Gene Names Primary:
PTPN4
Organism:
Homo sapiens (Human)

Structure

Length:
926
Sequence:
MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
May act at junctions between the membrane and the cytoskeleton.
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 852 852 Phosphocysteine intermediate.
Cross Reference Drug Bank:
DB00630
Gene Ontology Go:
cytoplasm
cytoplasmic side of plasma membrane
cytoskeleton
non-membrane spanning protein tyrosine phosphatase activity
protein dephosphorylation
Gene Ontology Biological Process:
protein dephosphorylation
Gene Ontology Molecular Function:
non-membrane spanning protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
cytoplasm
cytoplasmic side of plasma membrane
cytoskeleton
Keywords:
3D-structure
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome
Interacts With:
P46108; Q92993; P53778; P16333

Publication

PubMed ID:
1648233 14702039 15489334 8483328