Names & Taxonomy
- Uniprot ID:
- P28476
- Entry Name:
- GBRR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-aminobutyric acid receptor subunit rho-2 (GABA(A) receptor subunit rho-2) (GABA(C) receptor)
- Gene Names:
- GABRR2
- Gene Names Primary:
- GABRR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 465
- Sequence:
- MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.
- Cross Reference Drug Bank:
- DB00546 DB01558 DB01594 DB01559 DB00829 DB01215 DB01567 DB00690 DB00801 DB00683 DB01595 DB00842 DB01588 DB01589 DB00231 DB00897
- Gene Ontology Go:
- cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
signal transduction
synaptic transmission
transmembrane transport
transport
visual perception - Gene Ontology Biological Process:
- gamma-aminobutyric acid signaling pathway
ion transmembrane transport
signal transduction
synaptic transmission
transmembrane transport
transport
visual perception - Gene Ontology Molecular Function:
- chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity - Gene Ontology Cellular Component:
- cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- Alternative initiation
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Postsynaptic cell membrane
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport