Names & Taxonomy
- Uniprot ID:
- P27352
- Entry Name:
- IF_HUMAN
- Status:
- reviewed
- Protein Names:
- Gastric intrinsic factor (Intrinsic factor) (IF) (INF)
- Gene Names:
- GIF IFMH
- Gene Names Primary:
- GIF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 417
- Sequence:
- MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENWAPSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.
- Cross Reference Drug Bank:
- DB00115
- Gene Ontology Go:
- apical plasma membrane
endosome
extracellular region
extracellular space
lysosomal lumen
microvillus
cobalamin binding
cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- cobalamin binding
- Gene Ontology Cellular Component:
- apical plasma membrane
endosome
extracellular region
extracellular space
lysosomal lumen
microvillus - Keywords:
- 3D-structure
Alternative splicing
Cobalt
Cobalt transport
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion transport
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal
Transport